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RB1 Inducible Coiled Coil Protein 1 (RB1CC1)

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CC1; DRAGOU14; FIP200; 200 kDa FAK Family Kinase-Interacting Protein

RB1 Inducible Coiled Coil Protein 1 (RB1CC1)
CCC M108
HGNC 15574
MGI 1341850
PubMed 21795712
RGD 1309346
UniProt Q8TDY2
Wiki RB1CC1
RB1CC1 interacts with signaling pathways to coordinately regulate cell growth, cell proliferation, apoptosis, autophagy, and cell migration. This tumor suppressor also enhances retinoblastoma 1 gene expression in cancer cells. The cDNA encodes a deduced 1,594-amino acid protein containing a consensus nuclear localization signal (KPRK), a leucine zipper motif, and a coiled-coil structure. The protein showed a molecular mass of 180 kD by Western blot analysis. Nuclear localization was confirmed by cell fractionation and immunocytochemistry analysis. The RB1CC1 protein is a key regulator of the tumor suppressor gene RB1. It is localized in the nucleus and has been proposed to be a transcription factor because of its nuclear localization signal, leucine zipper motif, and coiled-coil structure.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RB1 Inducible Coiled Coil Protein 1 (RB1CC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RB1 Inducible Coiled Coil Protein 1 (RB1CC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RB1 Inducible Coiled Coil Protein 1 (RB1CC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RB1 Inducible Coiled Coil Protein 1 (RB1CC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for RB1 Inducible Coiled Coil Protein 1 (RB1CC1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RB1 Inducible Coiled Coil Protein 1 (RB1CC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RB1 Inducible Coiled Coil Protein 1 (RB1CC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RB1 Inducible Coiled Coil Protein 1 (RB1CC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RB1 Inducible Coiled Coil Protein 1 (RB1CC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for RB1 Inducible Coiled Coil Protein 1 (RB1CC1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RB1 Inducible Coiled Coil Protein 1 (RB1CC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RB1 Inducible Coiled Coil Protein 1 (RB1CC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RB1 Inducible Coiled Coil Protein 1 (RB1CC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RB1 Inducible Coiled Coil Protein 1 (RB1CC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for RB1 Inducible Coiled Coil Protein 1 (RB1CC1) ELISA Kit Customized Service Offer
  1. "Identification of RB1CC1, a novel human gene that can induce RB1 in various human cells."Oncogene 21:1295-1298(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence and analysis of human chromosome 8." Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Suppression of Pyk2 kinase and cellular activities by FIP200."J. Cell Biol. 149:423-430(2000) [PubMed] [Europe PMC] [Abstract]
  6. "Preferential expression of RB1-inducible coiled-coil 1 in terminal differentiated musculoskeletal cells."Am. J. Pathol. 161:359-364(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Isolation, characterization and mapping of the mouse and human RB1CC1 genes."Gene 291:29-34(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Regulation of focal adhesion kinase by a novel protein inhibitor FIP200."Mol. Biol. Cell 13:3178-3191(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Truncating mutations of RB1CC1 in human breast cancer."Nat. Genet. 31:285-288(2002) [PubMed] [Europe PMC] [Abstract]
  10. "RB1CC1 suppresses cell cycle progression through RB1 expression in human neoplastic cells."Int. J. Mol. Med. 12:767-769(2003) [PubMed] [Europe PMC] [Abstract]
  11. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  12. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Atg101, a novel mammalian autophagy protein interacting with Atg13."Autophagy 5:973-979(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy."Mol. Biol. Cell 20:1981-1991(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  18. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  19. "p53 inhibits autophagy by interacting with the human ortholog of yeast Atg17, RB1CC1/FIP200."Cell Cycle 10:2763-2769(2011) [PubMed] [Europe PMC] [Abstract]
  20. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  21. "ATG8 family proteins act as scaffolds for assembly of the ULK complex: sequence requirements for LC3-interacting region (LIR) motifs."J. Biol. Chem. 287:39275-39290(2012) [PubMed] [Europe PMC] [Abstract]
  22. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  23. "Somatic sequence alterations in twenty-one genes selected by expression profile analysis of breast carcinomas."Breast Cancer Res. 9:R5-R5(2007) [PubMed] [Europe PMC] [Abstract]
  24. "The COP1 E3-ligase interacts with FIP200, a key regulator of mammalian autophagy."BMC Biochem. 14:1-1(2013) [PubMed] [Europe PMC] [Abstract]
  25. "Interaction between FIP200 and ATG16L1 distinguishes ULK1 complex-dependent and -independent autophagy."Nat. Struct. Mol. Biol. 20:144-149(2013) [PubMed] [Europe PMC] [Abstract]