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RAP1A, Member Of RAS Oncogene Family (RAP1A)

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KREV-1; KREV1; RAP1; SMGP21; C21KG; GTP-binding protein smg p21A; Ras-related protein Krev-1

RAP1A, Member Of RAS Oncogene Family (RAP1A)
CCC M098
HGNC 9855
MGI 97852
PubMed 22621783
RGD 1359694
UniProt P62834
Wiki RAP1A
RAP1A belongs to the family of RAS-related proteins. The most striking difference between RAP proteins and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. The product of this gene counteracts the mitogenic function of RAS because it can interact with RAS GAPs and RAF in a competitive manner. Two transcript variants encoding the same protein have been identified for this gene.
RAS1-mediated signaling pathways in Drosophila are not influenced by RAP1 levels, suggesting that RAS1 and RAP1 function via distinct pathways. Moreover, a mutation that abolishes the putative cAMP-dependent kinase phosphorylation site of Drosophila RAP1 can still rescue the RAP1 mutant phenotype.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAP1A, Member Of RAS Oncogene Family (RAP1A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAP1A, Member Of RAS Oncogene Family (RAP1A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAP1A, Member Of RAS Oncogene Family (RAP1A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAP1A, Member Of RAS Oncogene Family (RAP1A) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAP1A, Member Of RAS Oncogene Family (RAP1A) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAP1A, Member Of RAS Oncogene Family (RAP1A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAP1A, Member Of RAS Oncogene Family (RAP1A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAP1A, Member Of RAS Oncogene Family (RAP1A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAP1A, Member Of RAS Oncogene Family (RAP1A) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAP1A, Member Of RAS Oncogene Family (RAP1A) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAP1A, Member Of RAS Oncogene Family (RAP1A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAP1A, Member Of RAS Oncogene Family (RAP1A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAP1A, Member Of RAS Oncogene Family (RAP1A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAP1A, Member Of RAS Oncogene Family (RAP1A) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAP1A, Member Of RAS Oncogene Family (RAP1A) ELISA Kit Customized Service Offer
  1. "Human cDNAs rap1 and rap2 homologous to the Drosophila gene Dras3 encode proteins closely related to ras in the 'effector' region."Oncogene 3:201-204(1988) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Purification, identification, and characterization of two GTP-binding proteins with molecular weights of 25,000 and 21,000 in human platelet cytosol. One is the rap1/smg21/Krev-1 protein and the other is a novel GTP-binding protein."J. Biol. Chem. 264:17000-17005(1989) [PubMed] [Europe PMC] [Abstract]
  5. "Purification and characterization of the 22,000-dalton GTP-binding protein substrate for ADP-ribosylation by botulinum toxin, G22K."J. Biol. Chem. 263:16744-16749(1988) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of a platelet Mr 22,000 GTP-binding protein as the novel smg-21 gene product having the same putative effector domain as the ras gene products."Biochem. Biophys. Res. Commun. 157:670-676(1988) [PubMed] [Europe PMC] [Abstract]
  7. "The COOH-terminal domain of the Rap1A (Krev-1) protein is isoprenylated and supports transformation by an H-Ras:Rap1A chimeric protein."Mol. Cell. Biol. 11:1523-1530(1991) [PubMed] [Europe PMC] [Abstract]
  8. "RA-GEF, a novel Rap1A guanine nucleotide exchange factor containing a Ras/Rap1A-associating domain, is conserved between nematode and humans."J. Biol. Chem. 274:37815-37820(1999) [PubMed] [Europe PMC] [Abstract]
  9. "Regulation of a novel human phospholipase C, PLCepsilon, through membrane targeting by Ras."J. Biol. Chem. 276:2752-2757(2001) [PubMed] [Europe PMC] [Abstract]
  10. "RA-GEF-1, a guanine nucleotide exchange factor for Rap1, is activated by translocation induced by association with Rap1*GTP and enhances Rap1-dependent B-Raf activation."J. Biol. Chem. 276:28478-28483(2001) [PubMed] [Europe PMC] [Abstract]
  11. "Differential roles of Ras and Rap1 in growth factor-dependent activation of phospholipase C epsilon."Oncogene 21:8105-8113(2002) [PubMed] [Europe PMC] [Abstract]
  12. "Krit 1 interactions with microtubules and membranes are regulated by Rap1 and integrin cytoplasmic domain associated protein-1."FEBS J. 274:5518-5532(2007) [PubMed] [Europe PMC] [Abstract]
  13. "A Rap GTPase interactor, RADIL, mediates migration of neural crest precursors."Genes Dev. 21:2131-2136(2007) [PubMed] [Europe PMC] [Abstract]
  14. "Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway."Genomics 90:249-260(2007) [PubMed] [Europe PMC] [Abstract]
  15. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  16. "Epac1 and PDZ-GEF cooperate in Rap1 mediated endothelial junction control."Cell. Signal. 23:2056-2064(2011) [PubMed] [Europe PMC] [Abstract]
  17. "The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue."Nature 375:554-560(1995) [PubMed] [Europe PMC] [Abstract]
  18. "Ras/Rap effector specificity determined by charge reversal."Nat. Struct. Biol. 3:723-729(1996) [PubMed] [Europe PMC] [Abstract]