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Ribosomal Protein S6 Kinase Alpha 4 (RPS6Ka4)

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MSK2; RSKB; 90 kDa ribosomal protein S6 kinase 4; Ribosomal protein kinase B; Nuclear mitogen- and stress-activated protein kinase 2

Ribosomal Protein S6 Kinase Alpha 4 (RPS6Ka4)
CCC M089
HGNC 10433
MGI 1930076
PubMed 9792677
UniProt O75676
Wiki RPS6KA4
RPS6Ka4 encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and c-fos. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
The predicted 772-amino acid protein contains 2 complete catalytic ser/thr kinase domains, both of which include 11 consensus kinase subdomains and conserved ATP-binding and activation domains. The N-terminal and C-terminal kinase domains of RSKB and ribosomal protein kinase 1 share 53% and 43% identity, respectively.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ribosomal Protein S6 Kinase Alpha 4 (RPS6Ka4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ribosomal Protein S6 Kinase Alpha 4 (RPS6Ka4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ribosomal Protein S6 Kinase Alpha 4 (RPS6Ka4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ribosomal Protein S6 Kinase Alpha 4 (RPS6Ka4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ribosomal Protein S6 Kinase Alpha 4 (RPS6Ka4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ribosomal Protein S6 Kinase Alpha 4 (RPS6Ka4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ribosomal Protein S6 Kinase Alpha 4 (RPS6Ka4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ribosomal Protein S6 Kinase Alpha 4 (RPS6Ka4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ribosomal Protein S6 Kinase Alpha 4 (RPS6Ka4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ribosomal Protein S6 Kinase Alpha 4 (RPS6Ka4) ELISA Kit Customized Service Offer
  1. "RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK)."J. Biol. Chem. 273:29661-29671(1998) [PubMed] [Europe PMC] [Abstract].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB."EMBO J. 17:4426-4441(1998) [PubMed] [Europe PMC] [Abstract]
  4. "C-terminal elements control location, activation threshold, and p38 docking of ribosomal S6 kinase B (RSKB)."J. Biol. Chem. 276:5892-5899(2001) [PubMed] [Europe PMC] [Abstract]
  5. "MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14."EMBO J. 22:2788-2797(2003) [PubMed] [Europe PMC] [Abstract]
  6. "MSK activation and physiological roles."Front. Biosci. 13:5866-5879(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  10. "The versatile role of MSKs in transcriptional regulation."Trends Biochem. Sci. 34:311-318(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  14. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]