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Ribosomal Protein S6 Kinase Alpha 3 (RPS6Ka3)

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RSK; CLS; HU3; ISPK1; MRX19; RSK2; pp90RSK2; Mental Retardation,X-linked 19; 90 kDa ribosomal S6 kinase 3; Insulin-stimulated protein kinase 1; Ribosomal S6 kinase 2

Ribosomal Protein S6 Kinase Alpha 3 (RPS6Ka3)
CCC M088
HGNC 10432
MGI 104557
PubMed 17100996
RGD 1563860
UniProt P51812
Wiki RPS6KA3
RPS6Ka3 encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation.The mouse Rsk3 gene was prominently expressed in the developing neural and sensory tissues, whereas Rsk1 gene expression was the strongest in various other tissues with high proliferative activity, suggesting distinct roles during development. In adult mouse brain, the highest levels of Rsk2 expression were observed in regions with high synaptic activity, including the neocortex, the hippocampus, and Purkinje cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ribosomal Protein S6 Kinase Alpha 3 (RPS6Ka3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ribosomal Protein S6 Kinase Alpha 3 (RPS6Ka3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ribosomal Protein S6 Kinase Alpha 3 (RPS6Ka3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ribosomal Protein S6 Kinase Alpha 3 (RPS6Ka3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ribosomal Protein S6 Kinase Alpha 3 (RPS6Ka3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ribosomal Protein S6 Kinase Alpha 3 (RPS6Ka3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ribosomal Protein S6 Kinase Alpha 3 (RPS6Ka3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ribosomal Protein S6 Kinase Alpha 3 (RPS6Ka3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ribosomal Protein S6 Kinase Alpha 3 (RPS6Ka3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ribosomal Protein S6 Kinase Alpha 3 (RPS6Ka3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ribosomal Protein S6 Kinase Alpha 3 (RPS6Ka3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ribosomal Protein S6 Kinase Alpha 3 (RPS6Ka3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ribosomal Protein S6 Kinase Alpha 3 (RPS6Ka3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ribosomal Protein S6 Kinase Alpha 3 (RPS6Ka3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ribosomal Protein S6 Kinase Alpha 3 (RPS6Ka3) ELISA Kit Customized Service Offer
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  20. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  21. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  22. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  23. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
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  25. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  26. "Mutations in the kinase Rsk-2 associated with Coffin-Lowry syndrome."Nature 384:567-570(1996) [PubMed] [Europe PMC] [Abstract]
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  30. "A missense mutation in RPS6KA3 (RSK2) responsible for non-specific mental retardation."Nat. Genet. 22:13-14(1999) [PubMed] [Europe PMC] [Abstract]
  31. "Intronic L1 insertion and F268S, novel mutations in RPS6KA3 (RSK2) causing Coffin-Lowry syndrome."Clin. Genet. 64:491-496(2003) [PubMed] [Europe PMC] [Abstract]
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