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Periodic Tryptophan Protein 2 (PWP2)

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EHOC-17; PWP2H

Periodic Tryptophan Protein 2 (PWP2)
CCC M073
HGNC 9711
MGI 1341200
PubMed 8973917
RGD 1582817
UniProt Q15269
Wiki PWP2
An exon was isolated that encoded a predicted protein which was similar to the yeast PWP2 gene, a member of the tryptophan-aspartate (WD) repeat-containing superfamily. PWP2 is essential for viability and may play a role in the early G1 phase of the cell cycle. The complete coding region of human PWP2, obtained from fetal brain and fetal kidney cDNA libraries, encodes a 919-amino acid predicted protein with over 40% identity to the yeast protein. It also shares similarity to the beta subunits of the trimeric G-protein family. The protein contains 5 complete WD repeats and an acidic domain between the second and third WD motifs. Northern blots showed a 3.4-kb PWP2 mRNA in all fetal and adult tissues examined. Based on cosmid contig analysis, the gene was mapped approximately 200 kb proximal to PFKL.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Periodic Tryptophan Protein 2 (PWP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Periodic Tryptophan Protein 2 (PWP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Periodic Tryptophan Protein 2 (PWP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Periodic Tryptophan Protein 2 (PWP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Periodic Tryptophan Protein 2 (PWP2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Periodic Tryptophan Protein 2 (PWP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Periodic Tryptophan Protein 2 (PWP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Periodic Tryptophan Protein 2 (PWP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Periodic Tryptophan Protein 2 (PWP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Periodic Tryptophan Protein 2 (PWP2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Periodic Tryptophan Protein 2 (PWP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Periodic Tryptophan Protein 2 (PWP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Periodic Tryptophan Protein 2 (PWP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Periodic Tryptophan Protein 2 (PWP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Periodic Tryptophan Protein 2 (PWP2) ELISA Kit Customized Service Offer
  1. "Cloning the cDNA of human PWP2, which encodes a protein with WD repeats and maps to 21q22.3."Genomics 35:321-327(1996) [PubMed] [Europe PMC] [Abstract]
  2. "A periodic tryptophan protein 2 gene homologue (PWP2H) in the candidate region of progressive myoclonus epilepsy on 21q22.3."Cytogenet. Cell Genet. 74:140-145(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Isolation and genomic structure of a human homolog of the yeast periodic tryptophan protein 2 (PWP2) gene mapping to 21q22.3."Genome Res. 6:1216-1226(1996) [PubMed] [Europe PMC] [Abstract]
  4. "Genomic organization and complete nucleotide sequence of the human PWP2 gene on chromosome 21."Genomics 42:528-531(1997) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence of human chromosome 21." Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Genomic organization and complete nucleotide sequence of the TMEM1 gene on human chromosome 21q22.3."Biochem. Biophys. Res. Commun. 235:185-190(1997) [PubMed] [Europe PMC] [Abstract]
  9. "Functional proteomic analysis of human nucleolus."Mol. Biol. Cell 13:4100-4109(2002) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]