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Pumilio Homolog 2 (PUM2)

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PUMH2; PUML2

Pumilio Homolog 2 (PUM2)
CCC M072
HGNC 14958
MGI 1931751
PubMed 21589936
RGD 1311024
UniProt Q8TB72
Wiki PUM2
A DAZ homolog, DAZ-like (DAZL), is found in diverse organisms, including humans, and is required for germ cell development in males and/or females.
PUM2, a human homolog of Pumilio, a protein required to maintain germline stem cells in Drosophila and C. elegans, forms a stable complex with DAZ through the same functional domain required for RNA binding, protein-protein interactions, and rescue from Pumilio mutations in flies. PUM2 is expressed predominantly in human embryonic stem cells and germ cells and colocalizes with DAZ and DAZL in germ cells. These data implicated PUM2 as a component of conserved cellular machinery that may be required for germ cell development.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pumilio Homolog 2 (PUM2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pumilio Homolog 2 (PUM2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pumilio Homolog 2 (PUM2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pumilio Homolog 2 (PUM2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pumilio Homolog 2 (PUM2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pumilio Homolog 2 (PUM2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pumilio Homolog 2 (PUM2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pumilio Homolog 2 (PUM2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pumilio Homolog 2 (PUM2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pumilio Homolog 2 (PUM2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pumilio Homolog 2 (PUM2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pumilio Homolog 2 (PUM2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pumilio Homolog 2 (PUM2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pumilio Homolog 2 (PUM2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pumilio Homolog 2 (PUM2) ELISA Kit Customized Service Offer
  1. "Cloning and comparative sequence analysis of PUM1 and PUM2 genes, human members of the Pumilio family of RNA-binding proteins."Gene 299:195-204(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Human Pumilio-2 is expressed in embryonic stem cells and germ cells and interacts with DAZ (Deleted in AZoospermia) and DAZ-like proteins."Proc. Natl. Acad. Sci. U.S.A. 100:538-543(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Genome-wide comparison of human keratinocyte and squamous cell carcinoma responses to UVB irradiation: implications for skin and epithelial cancer."Oncogene 22:2993-3006(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Conservation of a Pumilio-Nanos complex from Drosophila germ plasm to human germ cells."Dev. Genes Evol. 213:120-126(2003) [PubMed] [Europe PMC] [Abstract]
  10. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Comparative analysis of mRNA targets for human PUF-family proteins suggests extensive interaction with the miRNA regulatory system."PLoS ONE 3:E3164-E3164(2008) [PubMed] [Europe PMC] [Abstract]
  12. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  15. "The SNARE-associated component SNAPIN binds PUMILIO2 and NANOS1 proteins in human male germ cells."Mol. Hum. Reprod. 15:173-179(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  18. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  19. "NANOS1 and PUMILIO2 bind microRNA biogenesis factor GEMIN3, within chromatoid body in human germ cells."Histochem. Cell Biol. 136:279-287(2011) [PubMed] [Europe PMC] [Abstract]
  20. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  21. "Pumilio facilitates miRNA regulation of the E2F3 oncogene."Genes Dev. 26:356-368(2012) [PubMed] [Europe PMC] [Abstract]
  22. "Human Pumilio proteins recruit multiple deadenylases to efficiently repress messenger RNAs."J. Biol. Chem. 287:36370-36383(2012) [PubMed] [Europe PMC] [Abstract]
  23. "SCCRO3 (DCUN1D3) antagonizes the neddylation and oncogenic activity of SCCRO (DCUN1D1)."J. Biol. Chem. 289:34728-34742(2014) [PubMed] [Europe PMC] [Abstract]
  24. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  25. "A novel function of human Pumilio proteins in cytoplasmic sensing of viral infection."PLoS Pathog. 10:E1004417-E1004417(2014) [PubMed] [Europe PMC] [Abstract]
  26. "Alternate modes of cognate RNA recognition by human PUMILIO proteins."Structure 19:361-367(2011) [PubMed] [Europe PMC] [Abstract]