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Pumilio Homolog 1 (PUM1)

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HSPUM; PUMH; PUMH1; PUML1

Pumilio Homolog 1 (PUM1)
CCC M071
HGNC 14957
MGI 1931749
PubMed 18211679
RGD 1307190
UniProt Q14671
Wiki PUM1
PUM1encodes a member of the PUF family, evolutionarily conserved RNA-binding proteins related to the Pumilio proteins of Drosophila and the fem-3 mRNA binding factor proteins of C. elegans.
The encoded protein contains a sequence-specific RNA binding domain composed of eight repeats and N- and C-terminal flanking regions, and serves as a translational regulator of specific mRNAs by binding to their 3' untranslated regions. The evolutionarily conserved function of the encoded protein in invertebrates and lower vertebrates suggests that the human protein may be involved in translational regulation of embryogenesis, and cell development and differentiation. Alternatively spliced transcript variants encoding different isoforms have been described.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pumilio Homolog 1 (PUM1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pumilio Homolog 1 (PUM1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pumilio Homolog 1 (PUM1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pumilio Homolog 1 (PUM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pumilio Homolog 1 (PUM1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pumilio Homolog 1 (PUM1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pumilio Homolog 1 (PUM1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pumilio Homolog 1 (PUM1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pumilio Homolog 1 (PUM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pumilio Homolog 1 (PUM1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pumilio Homolog 1 (PUM1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pumilio Homolog 1 (PUM1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pumilio Homolog 1 (PUM1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pumilio Homolog 1 (PUM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pumilio Homolog 1 (PUM1) ELISA Kit Customized Service Offer
  1. "Cloning and comparative sequence analysis of PUM1 and PUM2 genes, human members of the Pumilio family of RNA-binding proteins."Gene 299:195-204(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1."DNA Res. 2:37-43(1995) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Genome-wide comparison of human keratinocyte and squamous cell carcinoma responses to UVB irradiation: implications for skin and epithelial cancer."Oncogene 22:2993-3006(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Comparative analysis of mRNA targets for human PUF-family proteins suggests extensive interaction with the miRNA regulatory system."PLoS ONE 3:E3164-E3164(2008) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  12. "A Pumilio-induced RNA structure switch in p27-3' UTR controls miR-221 and miR-222 accessibility."Nat. Cell Biol. 12:1014-1020(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  14. "A structural-based statistical approach suggests a cooperative activity of PUM1 and miR-410 in human 3'-untranslated regions."Silence 1:17-17(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  16. "A universal code for RNA recognition by PUF proteins."Nat. Chem. Biol. 7:425-427(2011) [PubMed] [Europe PMC] [Abstract]
  17. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  18. "Pumilio facilitates miRNA regulation of the E2F3 oncogene."Genes Dev. 26:356-368(2012) [PubMed] [Europe PMC] [Abstract]
  19. "Human Pumilio proteins recruit multiple deadenylases to efficiently repress messenger RNAs."J. Biol. Chem. 287:36370-36383(2012) [PubMed] [Europe PMC] [Abstract]
  20. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  21. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  22. "A novel function of human Pumilio proteins in cytoplasmic sensing of viral infection."PLoS Pathog. 10:E1004417-E1004417(2014) [PubMed] [Europe PMC] [Abstract]
  23. "Pumilio1 haploinsufficiency leads to SCA1-like neurodegeneration by increasing wild-type Ataxin1 levels."Cell 160:1087-1098(2015) [PubMed] [Europe PMC] [Abstract]
  24. "Crystal structure of a Pumilio homology domain."Mol. Cell 7:855-865(2001) [PubMed] [Europe PMC] [Abstract]
  25. "Modular recognition of RNA by a human pumilio-homology domain."Cell 110:501-512(2002) [PubMed] [Europe PMC] [Abstract]
  26. "Structures of human Pumilio with noncognate RNAs reveal molecular mechanisms for binding promiscuity."Structure 16:549-557(2008) [PubMed] [Europe PMC] [Abstract]
  27. "Specific and modular binding code for cytosine recognition in Pumilio/FBF (PUF) RNA-binding domains."J. Biol. Chem. 286:26732-26742(2011) [PubMed] [Europe PMC] [Abstract]
  28. "Alternate modes of cognate RNA recognition by human PUMILIO proteins."Structure 19:361-367(2011) [PubMed] [Europe PMC] [Abstract]