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Protein Kinase, cAMP Dependent Catalytic Gamma (PRKACg)

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KAPG

Protein Kinase, cAMP Dependent Catalytic Gamma (PRKACg)
CCC M061
HGNC 9382
PubMed 2342480
UniProt P22612
Wiki PRKACG
Cyclic AMP-dependent protein kinase (PKA) consists of two catalytic subunits and a regulatory subunit dimer. This gene encodes the gamma form of its catalytic subunit. The gene is intronless and is thought to be a retrotransposon derived from the gene for the alpha form of the PKA catalytic subunit.
The PRKACG gene is intronless, contains remnants of a poly(A) tail, is flanked by direct repeats, and is colinear with the PRKACA gene. Thus, the authors concluded that the PRKACG gene is a PRKACA-derived retroposon. Northern blot analysis detected PRKACG expression in fractionated germ cells of human testes.Whereas at the amino acid level C-alpha and C-beta showed 93% homology, C-gamma showed only about 80% homology to both C-alpha and C-beta.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Kinase, cAMP Dependent Catalytic Gamma (PRKACg) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Kinase, cAMP Dependent Catalytic Gamma (PRKACg) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Kinase, cAMP Dependent Catalytic Gamma (PRKACg) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Kinase, cAMP Dependent Catalytic Gamma (PRKACg) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Kinase, cAMP Dependent Catalytic Gamma (PRKACg) ELISA Kit Customized Service Offer
  1. "Molecular cloning of a tissue-specific protein kinase (C gamma) from human testis -- representing a third isoform for the catalytic subunit of cAMP-dependent protein kinase."Mol. Endocrinol. 4:465-475(1990) [PubMed] [Europe PMC] [Abstract]
  2. "The gene encoding the C gamma catalytic subunit of cAMP-dependent protein kinase is a transcribed retroposon."Genomics 49:290-297(1998) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "A new form of macrothrombocytopenia induced by a germ-line mutation in the PRKACG gene."Blood 124:2554-2563(2014) [PubMed] [Europe PMC] [Abstract]
  6. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]