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PR Domain Containing Protein 2 (PRDM2)

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HUMHOXY1; MTB-ZF; RIZ; RIZ1; RIZ2; KMT8; Retinoblastoma Protein-Interacting Zinc Finger Protein; MTE-Binding Protein; Zinc-Finger DNA-Binding Protein

PR Domain Containing Protein 2 (PRDM2)
CCC M059
HGNC 9347
MGI 107628
PubMed 14633678
RGD 1594531
UniProt Q13029
Wiki PRDM2
PRDM2 is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action. Three transcript variants encoding different isoforms have been found for this gene.Highly expressed in retinoblastoma cell lines and in brain tumors. Also expressed in a number of other cell lines and in brain, heart, skeletal muscle, liver and spleen.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant PR Domain Containing Protein 2 (PRDM2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to PR Domain Containing Protein 2 (PRDM2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to PR Domain Containing Protein 2 (PRDM2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for PR Domain Containing Protein 2 (PRDM2) CLIA Kit Customized Service Offer
n/a ELISA Kit for PR Domain Containing Protein 2 (PRDM2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant PR Domain Containing Protein 2 (PRDM2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to PR Domain Containing Protein 2 (PRDM2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to PR Domain Containing Protein 2 (PRDM2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for PR Domain Containing Protein 2 (PRDM2) CLIA Kit Customized Service Offer
n/a ELISA Kit for PR Domain Containing Protein 2 (PRDM2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant PR Domain Containing Protein 2 (PRDM2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to PR Domain Containing Protein 2 (PRDM2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to PR Domain Containing Protein 2 (PRDM2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for PR Domain Containing Protein 2 (PRDM2) CLIA Kit Customized Service Offer
n/a ELISA Kit for PR Domain Containing Protein 2 (PRDM2) ELISA Kit Customized Service Offer
  1. "The retinoblastoma protein binds to RIZ, a zinc-finger protein that shares an epitope with the adenovirus E1A protein."Proc. Natl. Acad. Sci. U.S.A. 92:4467-4471(1995) [PubMed] [Europe PMC] [Abstract]
  2. "The retinoblastoma interacting zinc finger gene RIZ produces a PR domain-lacking product through an internal promoter."J. Biol. Chem. 272:2984-2991(1997) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Identification and cloning of the G3B cDNA encoding a 3' segment of a protein binding to GATA-3."Gene 163:329-330(1995) [PubMed] [Europe PMC] [Abstract]
  7. "cDNA cloning of a novel protein containing two zinc-finger domains that may function as a transcription factor for the human heme-oxygenase-1 gene."Eur. J. Biochem. 235:471-479(1996) [PubMed] [Europe PMC] [Abstract]
  8. "Inactivation of a histone methyltransferase by mutations in human cancers."Cancer Res. 63:7619-7623(2003) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  12. "Structural studies of the SET domain from RIZ1 tumor suppressor."Biochem. Biophys. Res. Commun. 366:807-813(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Structural biology of human H3K9 methyltransferases."PLoS ONE 5:E8570-E8570(2010) [PubMed] [Europe PMC] [Abstract]