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Polymerase Delta Interacting Protein 1 (POLdIP1)

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BACURD1; KCTD13; PDIP1; BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1; Potassium Channel Tetramerisation Domain Containing 13

Polymerase Delta Interacting Protein 1 (POLdIP1)
CCC M047
HGNC 22234
MGI 1923739
RGD 735189
UniProt Q8WZ19
KCTD13 encodes a predicted 329-amino acid protein of 36.4 kD molecular mass, and shows 62% amino acid identity with B12 (TNFAIP1), a TNF early-response gene. Northern blot analysis showed ubiquitous expression of a 1.8-kb KCTD13 transcript, with highest expression levels in liver and kidney.
KCTD13 is a nuclear protein that colocalizes with PCNA at replication foci. KCTD13 binds to POLD2 and to PCNA in vitro, and GST pull-down assays demonstrated that KCTD13 binds these 2 proteins simultaneously. KCTD13 stimulates the polymerase activity of POLD2 when PCNA is present. Similar to that of TNFAIP1, KCTD13 expression is induced by TNF-alpha and by IL6.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Polymerase Delta Interacting Protein 1 (POLdIP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Polymerase Delta Interacting Protein 1 (POLdIP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Polymerase Delta Interacting Protein 1 (POLdIP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Polymerase Delta Interacting Protein 1 (POLdIP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Polymerase Delta Interacting Protein 1 (POLdIP1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Polymerase Delta Interacting Protein 1 (POLdIP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Polymerase Delta Interacting Protein 1 (POLdIP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Polymerase Delta Interacting Protein 1 (POLdIP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Polymerase Delta Interacting Protein 1 (POLdIP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Polymerase Delta Interacting Protein 1 (POLdIP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Polymerase Delta Interacting Protein 1 (POLdIP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Polymerase Delta Interacting Protein 1 (POLdIP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Polymerase Delta Interacting Protein 1 (POLdIP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Polymerase Delta Interacting Protein 1 (POLdIP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Polymerase Delta Interacting Protein 1 (POLdIP1) ELISA Kit Customized Service Offer
  1. "A tumor necrosis factor alpha- and interleukin 6-inducible protein that interacts with the small subunit of DNA polymerase delta and proliferating cell nuclear antigen."Proc. Natl. Acad. Sci. U.S.A. 98:11979-11984(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Large-scale cDNA transfection screening for genes related to cancer development and progression." Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Cullin mediates degradation of RhoA through evolutionarily conserved BTB adaptors to control actin cytoskeleton structure and cell movement."Mol. Cell 35:841-855(2009) [PubMed] [Europe PMC] [Abstract]