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Unc-119 Homolog (UNC119)

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HRG4; POC7; POC7A; POC7 Centriolar Protein A; Retinal protein 4

Unc-119 Homolog (UNC119)
CCC M034
HGNC 12565
MGI 1328357
PubMed 8576185
RGD 3942
UniProt Q13432
Wiki UNC119
HRG4 is enriched in the photoreceptors of the retina.HRG4 shares strong homology with the C. elegans unc119 protein and it can functionally complement the C. elegans unc119 mutation. It has been localized to the photoreceptor synapses in the outer plexiform layer of the retina, and suggested to play a role in the mechanism of photoreceptor neurotransmitter release through the synaptic vesicle cycle. Two transcript variants encoding different isoforms have been described for this gene.The predicted 240-amino acid human and rat proteins both contain an N-terminal region rich in proline and glycine followed by a region with a mixture of alpha helices, beta sheets, and turns. Sequence comparisons indicated that the proline-glycine domains of RRG4 and HRG4 share only 67% homology, while the rest of the sequence is 100% identical.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Unc-119 Homolog (UNC119) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Unc-119 Homolog (UNC119) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Unc-119 Homolog (UNC119) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Unc-119 Homolog (UNC119) CLIA Kit Customized Service Offer
n/a ELISA Kit for Unc-119 Homolog (UNC119) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Unc-119 Homolog (UNC119) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Unc-119 Homolog (UNC119) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Unc-119 Homolog (UNC119) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Unc-119 Homolog (UNC119) CLIA Kit Customized Service Offer
n/a ELISA Kit for Unc-119 Homolog (UNC119) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Unc-119 Homolog (UNC119) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Unc-119 Homolog (UNC119) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Unc-119 Homolog (UNC119) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Unc-119 Homolog (UNC119) CLIA Kit Customized Service Offer
n/a ELISA Kit for Unc-119 Homolog (UNC119) ELISA Kit Customized Service Offer
  1. "Cloning of the cDNA for a novel photoreceptor protein."J. Biol. Chem. 271:1797-1804(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Mammalian orthologs of C. elegans unc-119 highly expressed in photoreceptors."Invest. Ophthalmol. Vis. Sci. 39:2085-2094(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Characterization of the gene for HRG4 (UNC119), a novel photoreceptor synaptic protein homologous to unc-119."Genomics 57:446-450(1999) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method."Invest. Ophthalmol. Vis. Sci. 52:6662-6670(2011) [PubMed] [Europe PMC] [Abstract]
  6. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "HRG4 (UNC119) mutation found in cone-rod dystrophy causes retinal degeneration in a transgenic model."Invest. Ophthalmol. Vis. Sci. 41:3268-3277(2000) [PubMed] [Europe PMC] [Abstract]
  9. "ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins."J. Biol. Chem. 276:22826-22837(2001) [PubMed] [Europe PMC] [Abstract]
  10. "Identification of UNC119 as a novel activator of SRC-type tyrosine kinases."J. Biol. Chem. 278:8837-8845(2003) [PubMed] [Europe PMC] [Abstract]
  11. "Unc119, a novel activator of Lck/Fyn, is essential for T cell activation."J. Exp. Med. 199:369-379(2004) [PubMed] [Europe PMC] [Abstract]
  12. "Specificity of Arl2/Arl3 signaling is mediated by a ternary Arl3-effector-GAP complex."FEBS Lett. 582:2501-2507(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Unc119 protects from Shigella infection by inhibiting the Abl family kinases."PLoS ONE 4:E5211-E5211(2009) [PubMed] [Europe PMC] [Abstract]
  14. "An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium."Genes Dev. 25:2347-2360(2011) [PubMed] [Europe PMC] [Abstract]
  15. "UNC119a bridges the transmission of Fyn signals to Rab11, leading to the completion of cytokinesis."Cell Cycle 12:1303-1315(2013) [PubMed] [Europe PMC] [Abstract]
  16. "UNC119 is required for G protein trafficking in sensory neurons."Nat. Neurosci. 14:874-880(2011) [PubMed] [Europe PMC] [Abstract]
  17. "Structural basis for Arl3-specific release of myristoylated ciliary cargo from UNC119."EMBO J. 31:4085-4094(2012) [PubMed] [Europe PMC] [Abstract]
  18. "A mutation in the human Uncoordinated 119 gene impairs TCR signaling and is associated with CD4 lymphopenia."Blood 119:1399-1406(2012) [PubMed] [Europe PMC] [Abstract]