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Inositol Polyphosphate-5-Phosphatase 72kDa (INPP5E)

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PPI5PIV; Phosphatidylinositol 4,5-bisphosphate 5-phosphatase; Phosphatidylinositol polyphosphate 5-phosphatase type IV

Inositol Polyphosphate-5-Phosphatase 72kDa (INPP5E)
CCC M031
HGNC 21474
MGI 1927753
PubMed 19668215
UniProt Q9NRR6
Wiki INPP5E
INPP5E is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. Studies of the mouse counterpart suggest that this protein may hydrolyze phosphatidylinositol 3,4, 5-trisphosphate and phosphatidylinositol 3,5-bisphosphate on the cytoplasmic Golgi membrane and thereby regulate Golgi-vesicular trafficking.
INPP5E expressed in insect cells readily hydrolyzed PtdIns(3,4,5)P3 to PtdIns(3,4)P2 in a time- and concentration-dependent manner. It did not hydrolyze soluble inositol phosphate or other inositol lipids. Altering the detergent composition of the assay permitted INPP5E-mediated hydrolysis of PtdIns(4,5)P2 to PtdIns(4)P.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Inositol Polyphosphate-5-Phosphatase 72kDa (INPP5E) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Inositol Polyphosphate-5-Phosphatase 72kDa (INPP5E) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Inositol Polyphosphate-5-Phosphatase 72kDa (INPP5E) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Inositol Polyphosphate-5-Phosphatase 72kDa (INPP5E) CLIA Kit Customized Service Offer
n/a ELISA Kit for Inositol Polyphosphate-5-Phosphatase 72kDa (INPP5E) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Inositol Polyphosphate-5-Phosphatase 72kDa (INPP5E) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Inositol Polyphosphate-5-Phosphatase 72kDa (INPP5E) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Inositol Polyphosphate-5-Phosphatase 72kDa (INPP5E) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Inositol Polyphosphate-5-Phosphatase 72kDa (INPP5E) CLIA Kit Customized Service Offer
n/a ELISA Kit for Inositol Polyphosphate-5-Phosphatase 72kDa (INPP5E) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Inositol Polyphosphate-5-Phosphatase 72kDa (INPP5E) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Inositol Polyphosphate-5-Phosphatase 72kDa (INPP5E) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Inositol Polyphosphate-5-Phosphatase 72kDa (INPP5E) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Inositol Polyphosphate-5-Phosphatase 72kDa (INPP5E) CLIA Kit Customized Service Offer
n/a ELISA Kit for Inositol Polyphosphate-5-Phosphatase 72kDa (INPP5E) ELISA Kit Customized Service Offer
  1. "The isolation and characterization of a cDNA encoding phospholipid-specific inositol polyphosphate 5-phosphatase."J. Biol. Chem. 275:20110-20116(2000) [PubMed] [Europe PMC] [Abstract]
  2. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  5. "INPP5E mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in human and mouse."Nat. Genet. 41:1027-1031(2009) [PubMed] [Europe PMC] [Abstract]
  6. "Mutations in INPP5E, encoding inositol polyphosphate-5-phosphatase E, link phosphatidyl inositol signaling to the ciliopathies." Nat. Genet. 41:1032-1036(2009) [PubMed] [Europe PMC] [Abstract]
  7. "A homozygous PDE6D mutation in Joubert syndrome impairs targeting of farnesylated INPP5E protein to the primary cilium." Hum. Mutat. 35:137-146(2014) [PubMed] [Europe PMC] [Abstract]
  8. "Crystal structure of human INPP5E."Submitted (NOV-2010) to the PDB data bank