≡

Plexin Domain Containing Protein 1 (PLXDC1)

[Edit]

TEM3; TEM7; Tumor Endothelial Marker 7 Precursor

Plexin Domain Containing Protein 1 (PLXDC1)
CCC M027
HGNC 20945
MGI 1919574
PubMed 20919742
RGD 1307496
UniProt Q8IUK5
Wiki PLXDC1
TEM7 was expressed clearly in the endothelial cells of the tumor stroma but not in the endothelial cells of normal colonic tissue. Using in situ hybridization to assay expression in various normal adult mouse tissues, they observed that Tem7 was largely undetectable in mouse tissues or tumors, but was abundantly expressed in mouse brain.
TEM7 coding region, which encodes a 500-amino acid type I transmembrane protein containing a plexin-like domain. TEM3 and TEM7 differ in the use of alternative polyadenylation sites but result in the same predicted protein. The mouse ortholog of TEM7 shares 81% amino acid identity with the human protein.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Plexin Domain Containing Protein 1 (PLXDC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Plexin Domain Containing Protein 1 (PLXDC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Plexin Domain Containing Protein 1 (PLXDC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Plexin Domain Containing Protein 1 (PLXDC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Plexin Domain Containing Protein 1 (PLXDC1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Plexin Domain Containing Protein 1 (PLXDC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Plexin Domain Containing Protein 1 (PLXDC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Plexin Domain Containing Protein 1 (PLXDC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Plexin Domain Containing Protein 1 (PLXDC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Plexin Domain Containing Protein 1 (PLXDC1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Plexin Domain Containing Protein 1 (PLXDC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Plexin Domain Containing Protein 1 (PLXDC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Plexin Domain Containing Protein 1 (PLXDC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Plexin Domain Containing Protein 1 (PLXDC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Plexin Domain Containing Protein 1 (PLXDC1) ELISA Kit Customized Service Offer
  1. "Genes expressed in human tumor endothelium."Science 289:1197-1202(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Cell surface tumor endothelial markers are conserved in mice and humans."Cancer Res. 61:6649-6655(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Identification of a binding partner for the endothelial cell surface proteins TEM7 and TEM7R."Cancer Res. 64:8507-8511(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of the basement membrane protein nidogen as a candidate ligand for tumor endothelial marker 7 in vitro and in vivo."FEBS Lett. 580:2253-2257(2006) [PubMed] [Europe PMC] [Abstract]
  7. "High expression of tumor endothelial marker 7 is associated with metastasis and poor survival of patients with osteogenic sarcoma."Gene 399:137-143(2007) [PubMed] [Europe PMC] [Abstract]
  8. "TEM7 (PLXDC1) in neovascular endothelial cells of fibrovascular membranes from patients with proliferative diabetic retinopathy."Invest. Ophthalmol. Vis. Sci. 49:3151-3157(2008) [PubMed] [Europe PMC] [Abstract]