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Pleckstrin Homology Domain Containing Family O, Member 1 (PLEKHO1)

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CKIP-1; OC120; JBP; C-Jun-binding protein; Casein kinase 2-interacting protein 1; Osteoclast maturation-associated gene 120 protein

Pleckstrin Homology Domain Containing Family O, Member 1 (PLEKHO1)
CCC M026
HGNC 24310
MGI 1914470
PubMed 22286306
RGD 1311487
UniProt Q53GL0
Wiki PLEKHO1
CKIP1 interacted with full-length CSNK2A1 or with the N terminus of CSNK2A1. CKIP1 did not interact with CSNK2A2 or CSNK2B. The immunoprecipitated proteins showed CK2 activity.The deduced 409-amino acid protein has an N-terminal pleckstrin homology domain and a putative C-terminal JUN leucine zipper interactive domain. Northern blot analysis detected a major 1.5-kb transcript and a minor 4.4-kb transcript expressed at highest levels in skeletal muscle and heart. Intermediate expression was detected in brain, placenta, and lung, and weak expression was detected in liver, kidney, and pancreas. Fluorescence-tagged CKIP1 localized at the plasma membrane of transfected COS-7 cells. In human osteosarcoma cells, CKIP1 localized within the nucleus and at the plasma membrane.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pleckstrin Homology Domain Containing Family O, Member 1 (PLEKHO1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pleckstrin Homology Domain Containing Family O, Member 1 (PLEKHO1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pleckstrin Homology Domain Containing Family O, Member 1 (PLEKHO1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pleckstrin Homology Domain Containing Family O, Member 1 (PLEKHO1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pleckstrin Homology Domain Containing Family O, Member 1 (PLEKHO1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pleckstrin Homology Domain Containing Family O, Member 1 (PLEKHO1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pleckstrin Homology Domain Containing Family O, Member 1 (PLEKHO1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pleckstrin Homology Domain Containing Family O, Member 1 (PLEKHO1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pleckstrin Homology Domain Containing Family O, Member 1 (PLEKHO1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pleckstrin Homology Domain Containing Family O, Member 1 (PLEKHO1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pleckstrin Homology Domain Containing Family O, Member 1 (PLEKHO1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pleckstrin Homology Domain Containing Family O, Member 1 (PLEKHO1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pleckstrin Homology Domain Containing Family O, Member 1 (PLEKHO1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pleckstrin Homology Domain Containing Family O, Member 1 (PLEKHO1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pleckstrin Homology Domain Containing Family O, Member 1 (PLEKHO1) ELISA Kit Customized Service Offer
  1. "Identification and characterization of CKIP-1, a novel pleckstrin homology domain-containing protein that interacts with protein kinase CK2."J. Biol. Chem. 275:14295-14306(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Role for the pleckstrin homology domain-containing protein CKIP-1 in AP-1 regulation and apoptosis."EMBO J. 24:766-778(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs."Genome Res. 11:1392-1403(2001) [PubMed] [Europe PMC] [Abstract]
  6. "Functional specialization of CK2 isoforms and characterization of isoform-specific binding partners."Mol. Cell. Biochem. 227:21-29(2001) [PubMed] [Europe PMC] [Abstract]
  7. "The pleckstrin homology domain of CK2 interacting protein-1 is required for interactions and recruitment of protein kinase CK2 to the plasma membrane."J. Biol. Chem. 279:42114-42127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Role for the pleckstrin homology domain-containing protein CKIP-1 in phosphatidylinositol 3-kinase-regulated muscle differentiation."Mol. Cell. Biol. 24:1245-1255(2004) [PubMed] [Europe PMC] [Abstract]
  9. "The pleckstrin homology domain-containing protein CKIP-1 is involved in regulation of cell morphology and the actin cytoskeleton and interaction with actin capping protein."Mol. Cell. Biol. 25:3519-3534(2005) [PubMed] [Europe PMC] [Abstract]
  10. "CKIP-1 recruits nuclear ATM partially to the plasma membrane through interaction with ATM."Cell. Signal. 18:1386-1395(2006) [PubMed] [Europe PMC] [Abstract]
  11. "The role of CKIP-1 in cell morphology depends on its interaction with actin-capping protein."J. Biol. Chem. 281:36347-36359(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Casein kinase 2-interacting protein-1, a novel Akt pleckstrin homology domain-interacting protein, down-regulates PI3K/Akt signaling and suppresses tumor growth in vivo."Cancer Res. 67:9666-9676(2007) [PubMed] [Europe PMC] [Abstract]
  13. "The PH domain containing protein CKIP-1 binds to IFP35 and Nmi and is involved in cytokine signaling."Cell. Signal. 19:932-944(2007) [PubMed] [Europe PMC] [Abstract]