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Piwi Like Protein 1 (PIWIL1)

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HIWI; PIWI

Piwi Like Protein 1 (PIWIL1)
CCC M019
HGNC 9007
MGI 1928897
PubMed 23523368
RGD 1306980
UniProt Q96J94
Wiki PIWIL1
PIWIL1 encodes a member of the PIWI subfamily of Argonaute proteins, evolutionarily conserved proteins containing both PAZ and Piwi motifs that play important roles in stem cell self-renewal, RNA silencing, and translational regulation in diverse organisms. The encoded protein may play a role as an intrinsic regulator of the self-renewal capacity of germline and hematopoietic stem cells.
Miwi associated with both piRNAs and mRNAs in cytosolic ribonucleoprotein and polysome fractions of mouse testicular extract. As polysomes increased in early spermiogenesis, Miwi levels increased in polysome fractions. Moreover, Miwi associated with the mRNA cap-binding complex.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Piwi Like Protein 1 (PIWIL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Piwi Like Protein 1 (PIWIL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Piwi Like Protein 1 (PIWIL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Piwi Like Protein 1 (PIWIL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Piwi Like Protein 1 (PIWIL1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Piwi Like Protein 1 (PIWIL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Piwi Like Protein 1 (PIWIL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Piwi Like Protein 1 (PIWIL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Piwi Like Protein 1 (PIWIL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Piwi Like Protein 1 (PIWIL1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Piwi Like Protein 1 (PIWIL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Piwi Like Protein 1 (PIWIL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Piwi Like Protein 1 (PIWIL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Piwi Like Protein 1 (PIWIL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Piwi Like Protein 1 (PIWIL1) ELISA Kit Customized Service Offer
  1. "Human CD34+ stem cells express the hiwi gene, a human homologue of the Drosophila gene piwi."Blood 97:426-434(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular characterization of hiwi, a human member of the piwi gene family whose overexpression is correlated to seminomas."Oncogene 21:3988-3999(2002) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The induction of H3K9 methylation by PIWIL4 at the p16Ink4a locus."Biochem. Biophys. Res. Commun. 359:497-502(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of eight members of the Argonaute family in the human genome."Genomics 82:323-330(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer."EMBO Rep. 5:189-194(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Expression of hiwi gene in human gastric cancer was associated with proliferation of cancer cells."Int. J. Cancer 118:1922-1929(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Scanning of novel cancer/testis proteins by human testis proteomic analysis."Proteomics 13:1200-1210(2013) [PubMed] [Europe PMC] [Abstract]
  10. "Structural basis for piRNA 2'-O-methylated 3'-end recognition by Piwi PAZ (Piwi/Argonaute/Zwille) domains."Proc. Natl. Acad. Sci. U.S.A. 108:903-910(2011) [PubMed] [Europe PMC] [Abstract]