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Phosphoinositide-3-Kinase Regulatory Subunit 5 (PIK3R5)

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FOAP-2; P101-PI3K; Phosphatidylinositol 4,5-bisphosphate 3-kinase regulatory subunit; PtdIns-3-kinase p101

Phosphoinositide-3-Kinase Regulatory Subunit 5 (PIK3R5)
CCC M018
HGNC 30035
MGI 2443588
PubMed 22065524
RGD 1563261
UniProt Q8WYR1
Wiki PIK3R5
Receptor-regulated class I phosphoinositide 3-kinases (PI3Ks) phosphorylate the membrane lipid phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) to PtdIns(3,4,5)P3, which in turn recruits and activates cytosolic effectors involved in proliferation, survival, or chemotaxis.
PIK3R5 is a PI3K regulatory subunit .fluorescence-tagged porcine p101 and human p110-gamma (PIK3CG) interacted in transfected human embryonic kidney cells and retained the essential functions of wildtype heterodimeric PI3K-gamma. G protein-beta-gamma recruited PI3K-gamma from the cytosol to the membrane through interaction with the p101 subunit. Accordingly, p101 was required for G protein-mediated activation of PI3K-gamma.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphoinositide-3-Kinase Regulatory Subunit 5 (PIK3R5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphoinositide-3-Kinase Regulatory Subunit 5 (PIK3R5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphoinositide-3-Kinase Regulatory Subunit 5 (PIK3R5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphoinositide-3-Kinase Regulatory Subunit 5 (PIK3R5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphoinositide-3-Kinase Regulatory Subunit 5 (PIK3R5) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphoinositide-3-Kinase Regulatory Subunit 5 (PIK3R5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphoinositide-3-Kinase Regulatory Subunit 5 (PIK3R5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphoinositide-3-Kinase Regulatory Subunit 5 (PIK3R5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphoinositide-3-Kinase Regulatory Subunit 5 (PIK3R5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphoinositide-3-Kinase Regulatory Subunit 5 (PIK3R5) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphoinositide-3-Kinase Regulatory Subunit 5 (PIK3R5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphoinositide-3-Kinase Regulatory Subunit 5 (PIK3R5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphoinositide-3-Kinase Regulatory Subunit 5 (PIK3R5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphoinositide-3-Kinase Regulatory Subunit 5 (PIK3R5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphoinositide-3-Kinase Regulatory Subunit 5 (PIK3R5) ELISA Kit Customized Service Offer
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  2. "p84, a new Gbetagamma-activated regulatory subunit of the type IB phosphoinositide 3-kinase p110gamma."Curr. Biol. 15:566-570(2005) [PubMed] [Europe PMC] [Abstract]
  3. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  4. "A missense mutation in PIK3R5 gene in a family with ataxia and oculomotor apraxia."Hum. Mutat. 33:351-354(2012) [PubMed] [Europe PMC] [Abstract]
  5. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]