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Peptidase D (PEPD)

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PRD; Xaa-Pro Dipeptidase; Prolidase; Imidodipeptidase; Proline dipeptidase

Peptidase D (PEPD)
CCC M011
HGNC 8840
MGI 97542
PubMed 17145499
RGD 1594571
UniProt P12955
Wiki PEPD
Xaa-Pro dipeptidase is a cytosolic dipeptidase that hydrolyzes dipeptides with proline or hydroxyproline at the carboxy terminus (but not Pro-Pro). It is important in collagen metabolism because of the high levels of aminoacids.
encodes a member of the peptidase family. The protein forms a homodimer that hydrolyzes dipeptides or tripeptides with C-terminal proline or hydroxyproline residues. The enzyme serves an important role in the recycling of proline, and may be rate limiting for the production of collagen. Mutations in this gene result in prolidase deficiency, which is characterized by the excretion of large amount of di- and tri-peptides containing proline. Multiple transcript variants encoding different isoforms have been found for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPM011Hu01 Recombinant Peptidase D (PEPD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAM011Hu01 Polyclonal Antibody to Peptidase D (PEPD) WB; IHC; ICC; IP.
MAM011Hu21 Monoclonal Antibody to Peptidase D (PEPD) WB; IHC; ICC; IP.
Assay Kits SEM011Hu ELISA Kit for Peptidase D (PEPD) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Peptidase D (PEPD) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Peptidase D (PEPD) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Peptidase D (PEPD) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Peptidase D (PEPD) CLIA Kit Customized Service Offer
n/a ELISA Kit for Peptidase D (PEPD) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Peptidase D (PEPD) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Peptidase D (PEPD) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Peptidase D (PEPD) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Peptidase D (PEPD) CLIA Kit Customized Service Offer
n/a ELISA Kit for Peptidase D (PEPD) ELISA Kit Customized Service Offer
  1. "Primary structure and gene localization of human prolidase."J. Biol. Chem. 264:4476-4481(1989) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Cluster analysis of an extensive human breast cancer cell line protein expression map database."Proteomics 2:212-223(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  10. "Crystal structure of human prolidase: the molecular basis of PD disease."Submitted (FEB-2009) to the PDB data bank
  11. "A single nucleotide change in the prolidase gene in fibroblasts from two patients with polypeptide positive prolidase deficiency. Expression of the mutant enzyme in NIH 3T3 cells."J. Clin. Invest. 86:351-355(1990) [PubMed] [Europe PMC] [Abstract]
  12. "Four novel PEPD alleles causing prolidase deficiency."Am. J. Hum. Genet. 54:1014-1021(1994) [PubMed] [Europe PMC] [Abstract]
  13. "Expression and molecular analysis of mutations in prolidase deficiency."Am. J. Hum. Genet. 59:1035-1039(1996) [PubMed] [Europe PMC] [Abstract]
  14. "Mutation analysis of five new patients affected by prolidase deficiency: the lack of enzyme activity causes necrosis-like cell death in cultured fibroblasts."Hum. Genet. 111:314-322(2002) [PubMed] [Europe PMC] [Abstract]