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Paternally Expressed Protein 10 (PEG10)

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EDR; MAR2; MART2; MEF3L1; RGAG3; Embryonal carcinoma differentiation-regulated protein; Mammalian retrotransposon-derived protein 2; Myelin expression factor 3-like protein 1

Paternally Expressed Protein 10 (PEG10)
CCC M009
HGNC 14005
MGI 2157785
PubMed 11318613
UniProt Q86TG7
Wiki PEG10
PEG10 includes two overlapping reading frames of the same transcript encoding distinct isoforms. The shorter isoform has a CCHC-type zinc finger motif containing a sequence characteristic of gag proteins of most retroviruses and some retrotransposons, and it functions in part by interacting with members of the TGF-beta receptor family.
The longer isoform has the active-site DSG consensus sequence of the protease domain of pol proteins. The longer isoform is the result of -1 translational frameshifting that is also seen in some retroviruses. Expression of these two isoforms only comes from the paternal allele due to imprinting. Increased gene expression (as observed by an increase in mRNA levels) is associated with hepatocellular carcinomas.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Paternally Expressed Protein 10 (PEG10) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Paternally Expressed Protein 10 (PEG10) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Paternally Expressed Protein 10 (PEG10) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Paternally Expressed Protein 10 (PEG10) CLIA Kit Customized Service Offer
n/a ELISA Kit for Paternally Expressed Protein 10 (PEG10) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Paternally Expressed Protein 10 (PEG10) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Paternally Expressed Protein 10 (PEG10) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Paternally Expressed Protein 10 (PEG10) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Paternally Expressed Protein 10 (PEG10) CLIA Kit Customized Service Offer
n/a ELISA Kit for Paternally Expressed Protein 10 (PEG10) ELISA Kit Customized Service Offer
  1. "A retrotransposon-derived gene, PEG10, is a novel imprinted gene located on human chromosome 7q21."Genomics 73:232-237(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Temporal regulation of the expression of syncytin (HERV-W), maternally imprinted PEG10, and SGCE in human placenta."Biol. Reprod. 69:286-293(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Involvement of PEG10 in human hepatocellular carcinogenesis through interaction with SIAH1."Cancer Res. 63:3043-3048(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Human retroviral gag- and gag-pol-like proteins interact with the transforming growth factor-beta receptor activin receptor-like kinase 1."J. Biol. Chem. 280:8482-8493(2005) [PubMed] [Europe PMC] [Abstract]
  8. "PEG10 is a c-MYC target gene in cancer cells."Cancer Res. 66:665-672(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Overexpression of the paternally expressed gene 10 (PEG10) from the imprinted locus on chromosome 7q21 in high-risk B-cell chronic lymphocytic leukemia."Int. J. Cancer 121:1984-1993(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Mammalian gene PEG10 expresses two reading frames by high efficiency -1 frameshifting in embryonic-associated tissues."J. Biol. Chem. 282:37359-37369(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Androgen activates PEG10 to promote carcinogenesis in hepatic cancer cells."Oncogene 26:5741-5751(2007) [PubMed] [Europe PMC] [Abstract]
  12. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]