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PDZ Domain Containing RING Finger Protein 3 (PDZRN3)

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LNX3; SEMACAP3; Likely Ortholog Of Mouse SemaF Cytoplasmic Domain Associated Protein 3; Semaphorin cytoplasmic domain-associated protein 3; Ligand of Numb protein X 3

PDZ Domain Containing RING Finger Protein 3 (PDZRN3)
CCC M008
HGNC 17704
MGI 1933157
PubMed 23576576
RGD 1305250
UniProt Q9UPQ7
Wiki PDZRN3
By sequencing clones obtained from an adult brain cDNA library, Kikuno et al. (1999) cloned PDZRN3, which they designated KIAA1095. The deduced 1,098-amino acid protein contains a C3HC4 zinc finger motif. RT-PCR ELISA detected high expression in heart, whole brain, lung, skeletal muscle, ovary, spinal cord, thalamus, amygdala, and fetal whole brain. Lower expression was detected in kidney, testis, pancreas, adult and fetal liver, and all other specific brain regions tested. Lowest expression was detected in spleen.
The deduced 1,066-amino acid protein contains an N-terminal RING domain, followed by 2 PDZ domains and 2 C-terminal bipartite nuclear localization signals. PDZRN3 shares 59.9% amino acid identity with PDZRN4.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant PDZ Domain Containing RING Finger Protein 3 (PDZRN3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to PDZ Domain Containing RING Finger Protein 3 (PDZRN3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to PDZ Domain Containing RING Finger Protein 3 (PDZRN3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for PDZ Domain Containing RING Finger Protein 3 (PDZRN3) CLIA Kit Customized Service Offer
n/a ELISA Kit for PDZ Domain Containing RING Finger Protein 3 (PDZRN3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant PDZ Domain Containing RING Finger Protein 3 (PDZRN3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to PDZ Domain Containing RING Finger Protein 3 (PDZRN3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to PDZ Domain Containing RING Finger Protein 3 (PDZRN3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for PDZ Domain Containing RING Finger Protein 3 (PDZRN3) CLIA Kit Customized Service Offer
n/a ELISA Kit for PDZ Domain Containing RING Finger Protein 3 (PDZRN3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant PDZ Domain Containing RING Finger Protein 3 (PDZRN3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to PDZ Domain Containing RING Finger Protein 3 (PDZRN3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to PDZ Domain Containing RING Finger Protein 3 (PDZRN3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for PDZ Domain Containing RING Finger Protein 3 (PDZRN3) CLIA Kit Customized Service Offer
n/a ELISA Kit for PDZ Domain Containing RING Finger Protein 3 (PDZRN3) ELISA Kit Customized Service Offer
  1. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "Identification and characterization of PDZRN3 and PDZRN4 genes in silico."Int. J. Mol. Med. 13:607-613(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Gene expression profiles in primary ovarian serous papillary tumors and normal ovarian epithelium: identification of candidate molecular markers for ovarian cancer diagnosis and therapy."Int. J. Cancer 112:14-25(2004) [PubMed] [Europe PMC] [Abstract]
  7. "PDZRN3 (LNX3, SEMCAP3) is required for the differentiation of C2C12 myoblasts into myotubes."J. Cell Sci. 119:5106-5113(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Solution structure of RSGI RUH-005, a PDZ domain in human cDNA, KIAA1095."Submitted (JAN-2004) to the PDB data bank
  9. "Solution structure of the fourth PDZ domain of KIAA1095 protein."Submitted (NOV-2004) to the PDB data bank