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PDZ And LIM Domain Protein 5 (PDLIM5)

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ENH; ENH1; L9; LIM; Enigma-like PDZ and LIM domains protein

PDZ And LIM Domain Protein 5 (PDLIM5)
CCC M005
HGNC 17468
MGI 1927489
PubMed 23593136
RGD 621076
UniProt Q96HC4
Wiki PDLIM5
PDLIM5 is a LIM domain protein. LIM domains are cysteine-rich double zinc fingers composed of 50 to 60 amino acids that are involved in protein-protein interactions. LIM domain-containing proteins are scaffolds for the formation of multiprotein complexes. The proteins are involved in cytoskeleton organization, cell lineage specification, organ development, and oncogenesis.
The encoded protein is also a member of the Enigma class of proteins, a family of proteins that possess a 100-amino acid PDZ domain in the N terminus and 1 to 3 LIM domains in the C terminus. Multiple transcript variants encoding different isoforms have been found for this gene, although not all of them have been fully characterized.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant PDZ And LIM Domain Protein 5 (PDLIM5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to PDZ And LIM Domain Protein 5 (PDLIM5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to PDZ And LIM Domain Protein 5 (PDLIM5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for PDZ And LIM Domain Protein 5 (PDLIM5) CLIA Kit Customized Service Offer
n/a ELISA Kit for PDZ And LIM Domain Protein 5 (PDLIM5) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant PDZ And LIM Domain Protein 5 (PDLIM5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to PDZ And LIM Domain Protein 5 (PDLIM5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to PDZ And LIM Domain Protein 5 (PDLIM5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for PDZ And LIM Domain Protein 5 (PDLIM5) CLIA Kit Customized Service Offer
n/a ELISA Kit for PDZ And LIM Domain Protein 5 (PDLIM5) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant PDZ And LIM Domain Protein 5 (PDLIM5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to PDZ And LIM Domain Protein 5 (PDLIM5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to PDZ And LIM Domain Protein 5 (PDLIM5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for PDZ And LIM Domain Protein 5 (PDLIM5) CLIA Kit Customized Service Offer
n/a ELISA Kit for PDZ And LIM Domain Protein 5 (PDLIM5) ELISA Kit Customized Service Offer
  1. "Isolation, tissue expression, and chromosomal assignment of a human LIM protein gene, showing homology to rat enigma homologue (ENH)."J. Hum. Genet. 44:256-260(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and identification of a novel human gene PDLIM5, a homolog of AD-associated neuronal thread protein (AD7c-NTP)."DNA Seq. 15:144-147(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer."Oncogene 23:7734-7745(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. , Submitted (NOV-2005) to UniProtKB
  9. "Gene expression and association analyses of LIM (PDLIM5) in bipolar disorder and schizophrenia."Mol. Psychiatry 10:1045-1055(2005) [PubMed] [Europe PMC] [Abstract]
  10. "A polymorphism in the PDLIM5 gene associated with gene expression and schizophrenia."Biol. Psychiatry 59:434-439(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
  13. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  16. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  17. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  18. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  19. "Solution structure of first LIM domain of enigma-like PDZ and LIM domains protein."Submitted (DEC-2006) to the PDB data bank
  20. "Unusual binding interactions in PDZ domain crystal structures help explain binding mechanisms."Protein Sci. 19:731-741(2010) [PubMed] [Europe PMC] [Abstract]
  21. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]