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PDZ And LIM Domain Protein 2 (PDLIM2)

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SLIM; PDZ-LIM protein mystique

PDZ And LIM Domain Protein 2 (PDLIM2)
CCC M002
HGNC 13992
MGI 2384850
PubMed 22731402
RGD 1359203
UniProt Q96JY6
Wiki PDLIM2
PDLIM2 clones in retina, lens, retinal pigment epithelium/choroid, and fetal eye cDNA libraries. Northern blot analysis detected high expression in rat cornea and lower expression in sclera, lung, and combined trabecular meshwork, iris, and ciliary body. No expression was detected in retina. In situ hybridization of rat eye tissues detected Pdlim2 in corneal epithelial cells, but not in corneal stroma or endothelium or in other ocular tissues.
Pdlim2 coimmunoprecipitated with Actn1, Actn4, filamin A (FLNA), and myosin heavy polypeptide-9 (MYH9) in rat corneal and lung extracts. Myosin VI (MYO6) coimmunoprecipitated with Pdlim2 from corneal but not lung extracts. Alpha-actinins were the most abundant immunoprecipitated proteins.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant PDZ And LIM Domain Protein 2 (PDLIM2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to PDZ And LIM Domain Protein 2 (PDLIM2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to PDZ And LIM Domain Protein 2 (PDLIM2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for PDZ And LIM Domain Protein 2 (PDLIM2) CLIA Kit Customized Service Offer
n/a ELISA Kit for PDZ And LIM Domain Protein 2 (PDLIM2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant PDZ And LIM Domain Protein 2 (PDLIM2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to PDZ And LIM Domain Protein 2 (PDLIM2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to PDZ And LIM Domain Protein 2 (PDLIM2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for PDZ And LIM Domain Protein 2 (PDLIM2) CLIA Kit Customized Service Offer
n/a ELISA Kit for PDZ And LIM Domain Protein 2 (PDLIM2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant PDZ And LIM Domain Protein 2 (PDLIM2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to PDZ And LIM Domain Protein 2 (PDLIM2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to PDZ And LIM Domain Protein 2 (PDLIM2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for PDZ And LIM Domain Protein 2 (PDLIM2) CLIA Kit Customized Service Offer
n/a ELISA Kit for PDZ And LIM Domain Protein 2 (PDLIM2) ELISA Kit Customized Service Offer
  1. "Large-scale cDNA transfection screening for genes related to cancer development and progression." Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Characterization of long cDNA clones from human adult spleen."DNA Res. 7:357-366(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence and analysis of human chromosome 8." Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Mystique is a new IGF-I regulated PDZ-LIM domain protein that promotes cell attachment and migration and suppresses anchorage independent growth."Mol. Biol. Cell 16:1811-1822(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  9. "Structure of the PDZ domain of human PDLIM2 bound to a C-terminal extension from human beta-tropomyosin."Submitted (FEB-2009) to the PDB data bank