≡

PDZ And LIM Domain Protein 1 (PDLIM1)

[Edit]

CLIM1; CLP-36; CLP36; ELFIN; hCLIM1; Carboxyl Terminal LIM Domain Protein 1; C-terminal LIM domain protein 1; LIM domain protein CLP-36

PDZ And LIM Domain Protein 1 (PDLIM1)
CCC M001
HGNC 2067
MGI 1860611
PubMed 19780892
RGD 68324
UniProt O00151
Wiki PDLIM1
The LIM domain of PDLIM1 interacts with the C-terminal EF-hand region of alpha-actinin-2 (ACTN2). Immunoprecipitation, Western blot analysis, and immunofluorescence microscopy demonstrated that the 36-kD PDLIM1 protein colocalizes with ACTN2 in the Z discs of myocardial sarcomeres, particularly at intercalated discs, and with vinculin (VCL), which is localized in the fascia adherens of intercalated discs.
Sequence analysis predicted that the 329-amino acid PDLIM1 protein, which is 88% homologous to the rat protein, shares 51 to 61% identity with the PDZ domains of ENIGMA, ALP, ENH, and RIL. SDS-PAGE analysis showed that recombinant PDLIM1 was expressed as a 36-kD protein.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPM001Hu01 Recombinant PDZ And LIM Domain Protein 1 (PDLIM1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAM001Hu21 Monoclonal Antibody to PDZ And LIM Domain Protein 1 (PDLIM1) WB; IHC; ICC; IP.
PAM001Hu01 Polyclonal Antibody to PDZ And LIM Domain Protein 1 (PDLIM1) WB; IHC; ICC; IP; FCM
Assay Kits SEM001Hu ELISA Kit for PDZ And LIM Domain Protein 1 (PDLIM1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant PDZ And LIM Domain Protein 1 (PDLIM1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to PDZ And LIM Domain Protein 1 (PDLIM1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to PDZ And LIM Domain Protein 1 (PDLIM1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for PDZ And LIM Domain Protein 1 (PDLIM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for PDZ And LIM Domain Protein 1 (PDLIM1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant PDZ And LIM Domain Protein 1 (PDLIM1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to PDZ And LIM Domain Protein 1 (PDLIM1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to PDZ And LIM Domain Protein 1 (PDLIM1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for PDZ And LIM Domain Protein 1 (PDLIM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for PDZ And LIM Domain Protein 1 (PDLIM1) ELISA Kit Customized Service Offer
  1. "Characterization of the human 36-kDa carboxyl terminal LIM domain protein (hCLIM1)."J. Cell. Biochem. 72:279-285(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Human CLP-36, a PDZ-domain and LIM-domain protein, binds to alpha-actinin-1 and associates with actin filaments and stress fibers in activated platelets and endothelial cells."Blood 96:4236-4245(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
  7. , Submitted (NOV-2005) to UniProtKB
  8. "Interaction of hCLIM1, an enigma family protein, with alpha-actinin 2."J. Cell. Biochem. 78:558-565(2000) [PubMed] [Europe PMC] [Abstract]
  9. "CLP-36 PDZ-LIM protein associates with nonmuscle alpha-actinin-1 and alpha-actinin-4."J. Biol. Chem. 275:11100-11105(2000) [PubMed] [Europe PMC] [Abstract]
  10. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
  12. "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
  13. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  14. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  18. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  19. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  20. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  21. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  22. "Solution structure of the LIM domain of carboxyl terminal LIM domain protein 1."Submitted (NOV-2005) to the PDB data bank