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PAX Interacting Protein 1 (PAXIP1)

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CAGF28; CAGF29; PACIP1; PAXIP1L; PTIP; TNRC2; PAX transactivation activation domain-interacting protein

PAX Interacting Protein 1 (PAXIP1)
CCC L992
HGNC 8624
MGI 1890430
PubMed 10908331
RGD 1307547
UniProt Q6ZW49
Wiki PAXIP1
PAXIP1 is a member of the paired box (PAX) gene family and encodes a nuclear protein with six BRCT (breast cancer carboxy-terminal) domains. This protein plays a critical role in maintaining genome stability, condensation of chromatin and progression through mitosis.
The deduced 1,056-amino acid protein has a calculated molecular mass of 119.3 kD. Ptip contains 2 N-terminal and 3 C-terminal BRCA1 (BRCT) domains separated by a glutamine-rich region. Northern blot analysis of mouse tissues detected ubiquitous expression of a 4.0-kb transcript, with highest expression in embryonic kidney and brain. PTIP was also expressed in all human and mouse cell lines examined. In mouse fibroblasts, Ptip localized to the nucleus.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant PAX Interacting Protein 1 (PAXIP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to PAX Interacting Protein 1 (PAXIP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to PAX Interacting Protein 1 (PAXIP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for PAX Interacting Protein 1 (PAXIP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for PAX Interacting Protein 1 (PAXIP1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant PAX Interacting Protein 1 (PAXIP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to PAX Interacting Protein 1 (PAXIP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to PAX Interacting Protein 1 (PAXIP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for PAX Interacting Protein 1 (PAXIP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for PAX Interacting Protein 1 (PAXIP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant PAX Interacting Protein 1 (PAXIP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to PAX Interacting Protein 1 (PAXIP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to PAX Interacting Protein 1 (PAXIP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for PAX Interacting Protein 1 (PAXIP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for PAX Interacting Protein 1 (PAXIP1) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  4. "cDNAs with long CAG trinucleotide repeats from human brain."Hum. Genet. 100:114-122(1997) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "BRCT repeats as phosphopeptide-binding modules involved in protein targeting."Science 302:636-639(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Human PTIP facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation."J. Biol. Chem. 279:55562-55569(2004) [PubMed] [Europe PMC] [Abstract]
  8. "The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex."Dev. Cell 13:580-592(2007) [PubMed] [Europe PMC] [Abstract]
  9. "PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex."J. Biol. Chem. 282:20395-20406(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth."Mol. Cell. Biol. 27:1889-1903(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Phospho-epitope binding by the BRCT domains of hPTIP controls multiple aspects of the cellular response to DNA damage."Nucleic Acids Res. 35:5312-5322(2007) [PubMed] [Europe PMC] [Abstract]
  12. "Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination."Science 318:447-450(2007) [PubMed] [Europe PMC] [Abstract]
  13. "PTIP/Swift is required for efficient PCNA ubiquitination in response to DNA damage."DNA Repair 7:775-787(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Biochemical characterisation of the SWI/SNF family member HLTF."Biochem. Biophys. Res. Commun. 390:187-191(2009) [PubMed] [Europe PMC] [Abstract]
  15. "PTIP promotes DNA double-strand break repair through homologous recombination."Genes Cells 15:243-254(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]