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PAS Domain Containing Serine/Threonine Protein Kinase (PASK)

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PASKIN; STK37

PAS Domain Containing Serine/Threonine Protein Kinase (PASK)
CCC L990
HGNC 17270
MGI 2155936
PubMed 11688972
RGD 1306146
UniProt Q96RG2
Wiki PASK
PAS domains regulate the function of many intracellular signaling pathways in response to both extrinsic and intrinsic stimuli. PASK is an evolutionarily conserved protein present in yeast, flies, and mammals.The 1,323-amino acid PASK protein contains 2 PAS domains, designated PAS-A and PAS-B, followed by a canonical serine/threonine kinase domain and a 75-amino acid hydrophilic tail. Human PASK purified from insect cells infected with a recombinant baculovirus encoding the full-length protein migrated on SDS-PAGE with an apparent molecular mass of 145 kD, similar to its predicted molecular mass. Transient transfection of human embryonic kidney cells with fluorescence-tagged PASK resulted in immunofluorescence that tended to predominate in the perinuclear region.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant PAS Domain Containing Serine/Threonine Protein Kinase (PASK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to PAS Domain Containing Serine/Threonine Protein Kinase (PASK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to PAS Domain Containing Serine/Threonine Protein Kinase (PASK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for PAS Domain Containing Serine/Threonine Protein Kinase (PASK) CLIA Kit Customized Service Offer
n/a ELISA Kit for PAS Domain Containing Serine/Threonine Protein Kinase (PASK) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant PAS Domain Containing Serine/Threonine Protein Kinase (PASK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to PAS Domain Containing Serine/Threonine Protein Kinase (PASK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to PAS Domain Containing Serine/Threonine Protein Kinase (PASK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for PAS Domain Containing Serine/Threonine Protein Kinase (PASK) CLIA Kit Customized Service Offer
n/a ELISA Kit for PAS Domain Containing Serine/Threonine Protein Kinase (PASK) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant PAS Domain Containing Serine/Threonine Protein Kinase (PASK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to PAS Domain Containing Serine/Threonine Protein Kinase (PASK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to PAS Domain Containing Serine/Threonine Protein Kinase (PASK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for PAS Domain Containing Serine/Threonine Protein Kinase (PASK) CLIA Kit Customized Service Offer
n/a ELISA Kit for PAS Domain Containing Serine/Threonine Protein Kinase (PASK) ELISA Kit Customized Service Offer
  1. "PAS kinase: an evolutionarily conserved PAS domain-regulated serine/threonine kinase."Proc. Natl. Acad. Sci. U.S.A. 98:8991-8996(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1."DNA Res. 2:167-174(1995) [PubMed] [Europe PMC] [Abstract]
  3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Large-scale concatenation cDNA sequencing."Genome Res. 7:353-358(1997) [PubMed] [Europe PMC] [Abstract]
  8. "Control of mammalian glycogen synthase by PAS kinase."Proc. Natl. Acad. Sci. U.S.A. 102:16596-16601(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Regulation by Per-Arnt-Sim (PAS) kinase of pancreatic duodenal homeobox-1 nuclear import in pancreatic beta-cells."Biochem. Soc. Trans. 34:791-793(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Male germ cell expression of the PAS domain kinase PASKIN and its novel target eukaryotic translation elongation factor eEF1A1."Cell. Physiol. Biochem. 20:227-240(2007) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Per-arnt-sim (PAS) domain-containing protein kinase is downregulated in human islets in type 2 diabetes and regulates glucagon secretion."Diabetologia 54:819-827(2011) [PubMed] [Europe PMC] [Abstract]
  14. "Substrate preference and phosphatidylinositol monophosphate inhibition of the catalytic domain of the Per-Arnt-Sim domain kinase PASKIN."FEBS J. 278:1757-1768(2011) [PubMed] [Europe PMC] [Abstract]
  15. "The PAS-domain kinase PASKIN: a new sensor in energy homeostasis."Cell. Mol. Life Sci. 66:876-883(2009) [PubMed] [Europe PMC] [Abstract]
  16. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  17. "Structure and interactions of PAS kinase N-terminal PAS domain: model for intramolecular kinase regulation."Structure 10:1349-1361(2002) [PubMed] [Europe PMC] [Abstract]
  18. "Structural bases of PAS domain-regulated kinase (PASK) activation in the absence of activation loop phosphorylation."J. Biol. Chem. 285:41034-41043(2010) [PubMed] [Europe PMC] [Abstract]
  19. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]