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Partitioning Defective 6 Homolog Alpha (PARD6a)

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PAR-6A; PAR6; PAR6C; PAR6alpha; TAX40; TIP-40; Tax interaction protein 40

Partitioning Defective 6 Homolog Alpha (PARD6a)
CCC L986
HGNC 15943
MGI 1927223
PubMed 15809027
RGD 1303273
UniProt Q9NPB6
Wiki PARD6A
PARD6a is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cell membrane protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. The protein also has a role in the epithelial-to-mesenchymal transition (EMT) that characterizes the invasive phenotype associated with metastatic carcinomas. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.The deduced protein contains a single PDZ domain. RNA dot-blot analysis revealed ubiquitous expression of PARD6A, with maximal expression in pituitary gland. High expression was also found in testis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Partitioning Defective 6 Homolog Alpha (PARD6a) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Partitioning Defective 6 Homolog Alpha (PARD6a) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Partitioning Defective 6 Homolog Alpha (PARD6a) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Partitioning Defective 6 Homolog Alpha (PARD6a) CLIA Kit Customized Service Offer
n/a ELISA Kit for Partitioning Defective 6 Homolog Alpha (PARD6a) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Partitioning Defective 6 Homolog Alpha (PARD6a) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Partitioning Defective 6 Homolog Alpha (PARD6a) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Partitioning Defective 6 Homolog Alpha (PARD6a) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Partitioning Defective 6 Homolog Alpha (PARD6a) CLIA Kit Customized Service Offer
n/a ELISA Kit for Partitioning Defective 6 Homolog Alpha (PARD6a) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Partitioning Defective 6 Homolog Alpha (PARD6a) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Partitioning Defective 6 Homolog Alpha (PARD6a) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Partitioning Defective 6 Homolog Alpha (PARD6a) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Partitioning Defective 6 Homolog Alpha (PARD6a) CLIA Kit Customized Service Offer
n/a ELISA Kit for Partitioning Defective 6 Homolog Alpha (PARD6a) ELISA Kit Customized Service Offer
  1. "The mammalian homologue of the Caenorhabditis elegans polarity protein PAR-6 is a binding partner for the Rho GTPases Cdc42 and Rac1."J. Cell Sci. 113:3267-3275(2000) [PubMed] [Europe PMC] [Abstract]
  2. "A human homolog of the Caenorhabditis elegans polarity determinant Par-6 links Rac and Cdc42 to PKC-zeta signaling and cell transformation."Curr. Biol. 10:697-707(2000) [PubMed] [Europe PMC] [Abstract]
  3. "The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42."Nat. Cell Biol. 2:531-539(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures."J. Cell Biol. 152:1183-1196(2001) [PubMed] [Europe PMC] [Abstract]
  5. "Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C."Genes Cells 6:107-119(2001) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins."Oncogene 16:643-654(1998) [PubMed] [Europe PMC] [Abstract]
  8. "Direct interaction of two polarity complexes implicated in epithelial tight junction assembly."Nat. Cell Biol. 5:137-142(2003) [PubMed] [Europe PMC] [Abstract]
  9. "CRB3 binds directly to Par6 and regulates the morphogenesis of the tight junctions in mammalian epithelial cells."Mol. Biol. Cell 15:1324-1333(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Nucleotide exchange factor ECT2 interacts with the polarity protein complex Par6/Par3/protein kinase Czeta (PKCzeta) and regulates PKCzeta activity."Mol. Cell. Biol. 24:6665-6675(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity."Science 307:1603-1609(2005) [PubMed] [Europe PMC] [Abstract]
  12. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  13. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Ect2 links the PKCiota-Par6alpha complex to Rac1 activation and cellular transformation."Oncogene 28:3597-3607(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Structure of a cell polarity regulator, a complex between atypical PKC and Par6 PB1 domains."J. Biol. Chem. 280:9653-9661(2005) [PubMed] [Europe PMC] [Abstract]