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Ribosomal Protein S6 Kinase Beta 1 (RPS6Kb1)

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PS6K; S6K; S6K1; STK14A; p70(S6K)-alpha; p70-S6K; p70-alpha; P70-S6 Kinase 1; 70 kDa ribosomal protein S6 kinase 1; Serine/threonine-protein kinase 14A

Ribosomal Protein S6 Kinase Beta 1 (RPS6Kb1)
CCC L979
HGNC 10436
MGI 1270849
PubMed 21035469
RGD 620683
UniProt P23443
Wiki RPS6KB1
RPS6KB1 encodes a member of the RSK (ribosomal s6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates several residues of the S6 ribosomal protein. The kinase activity of this protein leads to an increase in protein synthesis and cell proliferation. According to a May 2010 online news release by the Cincinnati Cancer Consortium with the Academic Health Center of the University of Cincinnati, inhibition of the S6K1 protein, or a lack of it, slows the production of adipose (fat) cells by disrupting and retarding the initial "commitment stage" of their formation. The study, led by cancer and cellular biologist and associate professor Dr. Sara Kozma, Ph.D., could have implications for the treatment of obesity.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL979Hu01 Recombinant Ribosomal Protein S6 Kinase Beta 1 (RPS6Kb1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAL979Hu01 Polyclonal Antibody to Ribosomal Protein S6 Kinase Beta 1 (RPS6Kb1) WB; IHC
MAL979Hu21 Monoclonal Antibody to Ribosomal Protein S6 Kinase Beta 1 (RPS6Kb1) WB; IHC; ICC; IP.
Assay Kits SEL979Hu ELISA Kit for Ribosomal Protein S6 Kinase Beta 1 (RPS6Kb1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ribosomal Protein S6 Kinase Beta 1 (RPS6Kb1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ribosomal Protein S6 Kinase Beta 1 (RPS6Kb1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ribosomal Protein S6 Kinase Beta 1 (RPS6Kb1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ribosomal Protein S6 Kinase Beta 1 (RPS6Kb1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ribosomal Protein S6 Kinase Beta 1 (RPS6Kb1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ribosomal Protein S6 Kinase Beta 1 (RPS6Kb1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ribosomal Protein S6 Kinase Beta 1 (RPS6Kb1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ribosomal Protein S6 Kinase Beta 1 (RPS6Kb1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ribosomal Protein S6 Kinase Beta 1 (RPS6Kb1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ribosomal Protein S6 Kinase Beta 1 (RPS6Kb1) ELISA Kit Customized Service Offer
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  10. "SKAR is a specific target of S6 kinase 1 in cell growth control."Curr. Biol. 14:1540-1549(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases."EMBO J. 23:1761-1769(2004) [PubMed] [Europe PMC] [Abstract]
  12. "mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E."Mol. Cell. Biol. 24:200-216(2004) [PubMed] [Europe PMC] [Abstract]
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  15. "S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth."Science 314:467-471(2006) [PubMed] [Europe PMC] [Abstract]
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  17. "S6K1-mediated disassembly of mitochondrial URI/PP1gamma complexes activates a negative feedback program that counters S6K1 survival signaling."Mol. Cell 28:28-40(2007) [PubMed] [Europe PMC] [Abstract]
  18. "mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)."Biochem. J. 416:375-385(2008) [PubMed] [Europe PMC] [Abstract]
  19. "S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-(alpha) signaling through IKK2."J. Biol. Chem. 283:35375-35382(2008) [PubMed] [Europe PMC] [Abstract]
  20. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  21. "Regulation and localization of ribosomal protein S6 kinase 1 isoforms."Growth Factors 27:12-21(2009) [PubMed] [Europe PMC] [Abstract]
  22. "Mechanism of PDK1-catalyzed Thr-229 phosphorylation of the S6K1 protein kinase."J. Biol. Chem. 284:22611-22624(2009) [PubMed] [Europe PMC] [Abstract]
  23. "Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1."Mol. Cell. Biol. 29:5657-5670(2009) [PubMed] [Europe PMC] [Abstract]
  24. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  25. "mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling."Mol. Cell. Biol. 30:908-921(2010) [PubMed] [Europe PMC] [Abstract]
  26. "Rictor is a novel target of p70 S6 kinase-1."Oncogene 29:1003-1016(2010) [PubMed] [Europe PMC] [Abstract]
  27. "Coordinate regulation of ribosome biogenesis and function by the ribosomal protein S6 kinase, a key mediator of mTOR function."Growth Factors 25:209-226(2007) [PubMed] [Europe PMC] [Abstract]
  28. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  29. "Functions and regulation of the 70kDa ribosomal S6 kinases."Int. J. Biochem. Cell Biol. 43:47-59(2011) [PubMed] [Europe PMC] [Abstract]
  30. "Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1."Science 339:1323-1328(2013) [PubMed] [Europe PMC] [Abstract]
  31. "Structural basis of human p70 ribosomal S6 kinase-1 regulation by activation loop phosphorylation."J. Biol. Chem. 285:4587-4594(2010) [PubMed] [Europe PMC] [Abstract]
  32. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
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