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NADH Dehydrogenase, Quinone 2 (NQO2)

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DHQV; DIA6; NMOR2; QR2; Quinone reductase 2; NRH dehydrogenase [quinone] 2; NRH:quinone oxidoreductase 2; Ribosyldihydronicotinamide dehydrogenase

NADH Dehydrogenase, Quinone 2 (NQO2)
CCC L968
HGNC 7856
MGI 104513
PubMed 11154737
RGD 1303320
UniProt P16083
Wiki NQO2
NQO2 is a phase II detoxification enzyme which can carry out two or four electron reductions. Its mechanism of reduction is via a covalently bound zinc ion and a cocrystalized FAD. NQO2 contains two chains homologous in AA sequence but 7% different in structure. As a result, NQO2 contains two similar yet unique active sites. An important function of NQO2 is its activation on NRH. NQO2 can be inhibited by resveratrol.NQO2 could bind estrone-3,4-quinone (E1-3,4-Q) and estradiol-3,4-quinone (E2-3,4-Q). Preliminary kinetic studies revealed that NQO2 was faster in reducing and deactivating the estrogen quinones than NQO1. The reduction of E1-3,4-Q and E2-3,4-Q by NQO2 was confirmed by ultraviolet and liquid chromatography-tandem mass spectrometry assays.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant NADH Dehydrogenase, Quinone 2 (NQO2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to NADH Dehydrogenase, Quinone 2 (NQO2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to NADH Dehydrogenase, Quinone 2 (NQO2) Polyclonal Antibody Customized Service Offer
Assay Kits SEL968Hu ELISA Kit for NADH Dehydrogenase, Quinone 2 (NQO2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant NADH Dehydrogenase, Quinone 2 (NQO2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to NADH Dehydrogenase, Quinone 2 (NQO2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to NADH Dehydrogenase, Quinone 2 (NQO2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for NADH Dehydrogenase, Quinone 2 (NQO2) CLIA Kit Customized Service Offer
n/a ELISA Kit for NADH Dehydrogenase, Quinone 2 (NQO2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant NADH Dehydrogenase, Quinone 2 (NQO2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to NADH Dehydrogenase, Quinone 2 (NQO2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to NADH Dehydrogenase, Quinone 2 (NQO2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for NADH Dehydrogenase, Quinone 2 (NQO2) CLIA Kit Customized Service Offer
n/a ELISA Kit for NADH Dehydrogenase, Quinone 2 (NQO2) ELISA Kit Customized Service Offer
  1. "Nucleotide and deduced amino acid sequence of a human cDNA (NQO2) corresponding to a second member of the NAD(P)H:quinone oxidoreductase gene family. Extensive polymorphism at the NQO2 gene locus on chromosome 6."Biochemistry 29:1899-1906(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Human NAD(P)H:quinone oxidoreductase 2. Gene structure, activity, and tissue-specific expression."J. Biol. Chem. 269:14502-14508(1994) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Catalytic properties of NAD(P)H:quinone oxidoreductase-2 (NQO2), a dihydronicotinamide riboside dependent oxidoreductase."Arch. Biochem. Biophys. 347:221-228(1997) [PubMed] [Europe PMC] [Abstract]
  7. "Unexpected genetic and structural relationships of a long-forgotten flavoenzyme to NAD(P)H:quinone reductase (DT-diaphorase)."Proc. Natl. Acad. Sci. U.S.A. 94:1669-1674(1997) [PubMed] [Europe PMC] [Abstract]
  8. ErratumProc. Natl. Acad. Sci. U.S.A. 94:5979-5979(1997)
  9. "Kinetic mechanism of quinone oxidoreductase 2 and its inhibition by the antimalarial quinolines."Biochemistry 43:4538-4547(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  13. "Crystal structure of human quinone reductase type 2, a metalloflavoprotein."Biochemistry 38:9881-9886(1999) [PubMed] [Europe PMC] [Abstract]
  14. "Crystal structure of quinone reductase 2 in complex with resveratrol."Biochemistry 43:11417-11426(2004) [PubMed] [Europe PMC] [Abstract]
  15. "Crystal structure of quinone reductase 2 in complex with cancer prodrug CB1954."Biochem. Biophys. Res. Commun. 336:332-338(2005) [PubMed] [Europe PMC] [Abstract]
  16. "Kinetic, thermodynamic and X-ray structural insights into the interaction of melatonin and analogues with quinone reductase 2."Biochem. J. 413:81-91(2008) [PubMed] [Europe PMC] [Abstract]
  17. "Quinone reductase 2 is a catechol quinone reductase."J. Biol. Chem. 283:23829-23835(2008) [PubMed] [Europe PMC] [Abstract]
  18. "The structure of the leukemia drug imatinib bound to human quinone reductase 2 (NQO2)."BMC Struct. Biol. 9:7-7(2009) [PubMed] [Europe PMC] [Abstract]