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Nucleolar Complex Associated 2 Homolog (NOC2L)

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NIR; NET7; NET15; NOC2-like protein; Novel INHAT repressor

Nucleolar Complex Associated 2 Homolog (NOC2L)
CCC L957
HGNC 24517
PubMed 20123734
UniProt Q9Y3T9
Wiki NOC2L
Histone modification by histone acetyltransferases (HAT) and histone deacetylases (HDAC) can control major aspects of transcriptional regulation. NOC2L represents a novel HDAC-independent inhibitor of histone acetyltransferase (INHAT).
The 749-amino acid protein contains an N-terminal and a C-terminal INHAT domain, as well as a putative bipartite nuclear localization signal. RT-PCR analysis showed Nir mRNA present at all analyzed stages of mouse embryogenesis. Dot-blot analysis found expression in all human adult tissues tested. Northern blot analysis showed a single 3.3-kb transcript.NIR repressed basal as well as activated transcription, and HDAC inhibitors did not block NIR-mediated repression of acetylation, showing that NIR functions independent of HDAC activity.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nucleolar Complex Associated 2 Homolog (NOC2L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nucleolar Complex Associated 2 Homolog (NOC2L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nucleolar Complex Associated 2 Homolog (NOC2L) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nucleolar Complex Associated 2 Homolog (NOC2L) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nucleolar Complex Associated 2 Homolog (NOC2L) ELISA Kit Customized Service Offer
  1. "NIR is a novel INHAT repressor that modulates the transcriptional activity of p53."Genes Dev. 19:2912-2924(2005) [PubMed] [Europe PMC] [Abstract]
  2. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Functional proteomic analysis of human nucleolus."Mol. Biol. Cell 13:4100-4109(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  11. "NIR, an inhibitor of histone acetyltransferases, regulates transcription factor TAp63 and is controlled by the cell cycle."Nucleic Acids Res. 38:3159-3171(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression."J. Biol. Chem. 286:2236-2244(2011) [PubMed] [Europe PMC] [Abstract]
  15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]