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Nuclear Factor Of Activated T-Cells, Cytoplasmic 4 (NFATC4)

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NF-ATc4; NFAT3; T-cell transcription factor NFAT3

Nuclear Factor Of Activated T-Cells, Cytoplasmic 4 (NFATC4)
CCC L944
HGNC 7778
MGI 1920431
PubMed 22586092
RGD 1310749
UniProt Q14934
Wiki NFATC4
NFATC4 is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family of nuclear factors of activated T cells also participate in the formation of this complex. The product of this gene plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of the IL-2 and IL-4.
Peptides spanning the region inhibit the ability of calcineurin to bind to and dephosphorylate NFAT proteins, without affecting the phosphatase activity of calcineurin against other substrates.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nuclear Factor Of Activated T-Cells, Cytoplasmic 4 (NFATC4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nuclear Factor Of Activated T-Cells, Cytoplasmic 4 (NFATC4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nuclear Factor Of Activated T-Cells, Cytoplasmic 4 (NFATC4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nuclear Factor Of Activated T-Cells, Cytoplasmic 4 (NFATC4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nuclear Factor Of Activated T-Cells, Cytoplasmic 4 (NFATC4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nuclear Factor Of Activated T-Cells, Cytoplasmic 4 (NFATC4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nuclear Factor Of Activated T-Cells, Cytoplasmic 4 (NFATC4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nuclear Factor Of Activated T-Cells, Cytoplasmic 4 (NFATC4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nuclear Factor Of Activated T-Cells, Cytoplasmic 4 (NFATC4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nuclear Factor Of Activated T-Cells, Cytoplasmic 4 (NFATC4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nuclear Factor Of Activated T-Cells, Cytoplasmic 4 (NFATC4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nuclear Factor Of Activated T-Cells, Cytoplasmic 4 (NFATC4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nuclear Factor Of Activated T-Cells, Cytoplasmic 4 (NFATC4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nuclear Factor Of Activated T-Cells, Cytoplasmic 4 (NFATC4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nuclear Factor Of Activated T-Cells, Cytoplasmic 4 (NFATC4) ELISA Kit Customized Service Offer
  1. "Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins."Immunity 2:461-472(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Alternative splicing and expression of human and mouse NFAT genes."Genomics 92:279-291(2008) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT."Cell 96:611-614(1999) [PubMed] [Europe PMC] [Abstract]
  6. "Requirement of two NFATc4 transactivation domains for CBP potentiation."J. Biol. Chem. 276:39569-39576(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Phosphorylation of NFATc4 by p38 mitogen-activated protein kinases."Mol. Cell. Biol. 22:3892-3904(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Nuclear factor of activated T3 is a negative regulator of Ras-JNK1/2-AP-1 induced cell transformation."Cancer Res. 67:8725-8735(2007) [PubMed] [Europe PMC] [Abstract]
  9. "RSK2 mediates muscle cell differentiation through regulation of NFAT3."J. Biol. Chem. 282:8380-8392(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Repression of NFAT3 transcriptional activity by estrogen receptors."Cell. Mol. Life Sci. 65:2752-2762(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Regulation of the stability and transcriptional activity of NFATc4 by ubiquitination."FEBS Lett. 582:4008-4014(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Integration of protein kinases mTOR and extracellular signal-regulated kinase 5 in regulating nucleocytoplasmic localization of NFATc4."Mol. Cell. Biol. 28:3489-3501(2008) [PubMed] [Europe PMC] [Abstract]
  14. "The interleukin-1 receptor associated kinase 1 contributes to the regulation of NFAT."Mol. Immunol. 45:3902-3908(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Solution structure of the TIG domain from human nuclear factor of activated T-cells, cytoplasmic 4."Submitted (FEB-2008) to the PDB data bank