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Never In Mitosis Gene A Related Kinase 9 (NEK9)

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NERCC; NERCC1; Nek8; Serine/threonine-protein kinase Nek9; NimA-related kinase 8

Never In Mitosis Gene A Related Kinase 9 (NEK9)
CCC L932
HGNC 18591
MGI 2387995
PubMed 21642957
UniProt Q8TD19
Wiki NEK9
NERCC1 has a nuclear localization signal between the N-terminal kinase domain and RCC1-like domain, and it has a polyglycine stretch and a ser/thr/pro-rich region, which includes 2 SH3 domain-binding PxxP motifs, between the RCC1-like domain and C-terminal coiled-coil domain.
The deduced 979-amino acid protein has an N-terminal kinase domain, a central RCC1-like domain, and a C-terminal coiled-coil domain. The catalytic domain shares significant similarity with those of NEK1, NEK3 , and NEK4. The RCC1-like domain is a 7-bladed propeller made up of beta strands. Northern blot analysis detected expression of Nek9 in all mouse tissues examined, with highest abundance in heart, liver, kidney, and testis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Never In Mitosis Gene A Related Kinase 9 (NEK9) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Never In Mitosis Gene A Related Kinase 9 (NEK9) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Never In Mitosis Gene A Related Kinase 9 (NEK9) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Never In Mitosis Gene A Related Kinase 9 (NEK9) CLIA Kit Customized Service Offer
n/a ELISA Kit for Never In Mitosis Gene A Related Kinase 9 (NEK9) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Never In Mitosis Gene A Related Kinase 9 (NEK9) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Never In Mitosis Gene A Related Kinase 9 (NEK9) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Never In Mitosis Gene A Related Kinase 9 (NEK9) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Never In Mitosis Gene A Related Kinase 9 (NEK9) CLIA Kit Customized Service Offer
n/a ELISA Kit for Never In Mitosis Gene A Related Kinase 9 (NEK9) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Never In Mitosis Gene A Related Kinase 9 (NEK9) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Never In Mitosis Gene A Related Kinase 9 (NEK9) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Never In Mitosis Gene A Related Kinase 9 (NEK9) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Never In Mitosis Gene A Related Kinase 9 (NEK9) CLIA Kit Customized Service Offer
n/a ELISA Kit for Never In Mitosis Gene A Related Kinase 9 (NEK9) ELISA Kit Customized Service Offer
  1. "Purification, cloning, and characterization of Nek8, a novel NIMA-related kinase, and its candidate substrate Bicd2."J. Biol. Chem. 277:16229-16240(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Nercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progression."Genes Dev. 16:1640-1658(2002) [PubMed] [Europe PMC] [Abstract]
  3. "Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method."DNA Res. 9:47-57(2002) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases."J. Biol. Chem. 278:34897-34909(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Nek9, a novel FACT-associated protein, modulates interphase progression."J. Biol. Chem. 279:9321-9330(2004) [PubMed] [Europe PMC] [Abstract]
  8. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  9. "The NIMA-family kinase Nek6 phosphorylates the kinesin Eg5 at a novel site necessary for mitotic spindle formation."J. Cell Sci. 121:3912-3921(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "An autoinhibitory tyrosine motif in the cell-cycle-regulated Nek7 kinase is released through binding of Nek9."Mol. Cell 36:560-570(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  17. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  18. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  19. "Structural analysis of the regulation of the DYNLL/LC8 binding to Nek9 by phosphorylation."J. Biol. Chem. 288:12283-12294(2013) [PubMed] [Europe PMC] [Abstract]
  20. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]