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Never In Mitosis Gene A Related Kinase 6 (NEK6)

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Putative Serine-Threonine Protein Kinase; Serine/threonine-protein kinase Nek6

Never In Mitosis Gene A Related Kinase 6 (NEK6)
CCC L931
HGNC 7749
MGI 1891638
PubMed 20407017
RGD 727779
UniProt Q9HC98
Wiki NEK6
The Aspergillus nidulans 'never in mitosis A' (NIMA) gene encodes a serine/threonine kinase that controls initiation of mitosis. NIMA-related kinases (NEKs) are a group of protein kinases that are homologous to NIMA. Evidence suggests that NEKs perform functions similar to those of NIMA.
Li et al. (1999) reported the cloning of a human liver cDNA encoding NEK6. Kimura and Okano (2001) determined that NEK6 and NEK7 share 77% amino acid identity. By Northern blot analysis, Li et al. (1999) detected 1.6-, 2.6-, and 9.5-kb NEK6 transcripts. The 1.6-kb transcript was expressed at highest levels in liver and placenta. By RT-PCR, Kimura and Okano (2001) found expression of NEK6 in all tissues examined.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Never In Mitosis Gene A Related Kinase 6 (NEK6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Never In Mitosis Gene A Related Kinase 6 (NEK6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Never In Mitosis Gene A Related Kinase 6 (NEK6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Never In Mitosis Gene A Related Kinase 6 (NEK6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Never In Mitosis Gene A Related Kinase 6 (NEK6) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Never In Mitosis Gene A Related Kinase 6 (NEK6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Never In Mitosis Gene A Related Kinase 6 (NEK6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Never In Mitosis Gene A Related Kinase 6 (NEK6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Never In Mitosis Gene A Related Kinase 6 (NEK6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Never In Mitosis Gene A Related Kinase 6 (NEK6) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Never In Mitosis Gene A Related Kinase 6 (NEK6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Never In Mitosis Gene A Related Kinase 6 (NEK6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Never In Mitosis Gene A Related Kinase 6 (NEK6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Never In Mitosis Gene A Related Kinase 6 (NEK6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Never In Mitosis Gene A Related Kinase 6 (NEK6) ELISA Kit Customized Service Offer
  1. "Identification and characterization of Nek6 protein kinase, a potential human homolog of NIMA histone H3 kinase."Biochem. Biophys. Res. Commun. 293:753-758(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases."J. Biol. Chem. 278:34897-34909(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The serine/threonine kinase Nek6 is required for cell cycle progression through mitosis."J. Biol. Chem. 278:52454-52460(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Interaction of Pin1 with Nek6 and characterization of their expression correlation in Chinese hepatocellular carcinoma patients."Biochem. Biophys. Res. Commun. 341:1059-1065(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Human NIMA-related kinase 6 is one of the Fe65 WW domain binding proteins."Biochem. Biophys. Res. Commun. 358:783-788(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Nek6 is involved in G2/M phase cell cycle arrest through DNA damage-induced phosphorylation."Cell Cycle 7:2705-2709(2008) [PubMed] [Europe PMC] [Abstract]
  10. "The NIMA-family kinase Nek6 phosphorylates the kinesin Eg5 at a novel site necessary for mitotic spindle formation."J. Cell Sci. 121:3912-3921(2008) [PubMed] [Europe PMC] [Abstract]
  11. "An autoinhibitory tyrosine motif in the cell-cycle-regulated Nek7 kinase is released through binding of Nek9."Mol. Cell 36:560-570(2009) [PubMed] [Europe PMC] [Abstract]
  12. "The Nek6 and Nek7 protein kinases are required for robust mitotic spindle formation and cytokinesis."Mol. Cell. Biol. 29:3975-3990(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Nek6 overexpression antagonizes p53-induced senescence in human cancer cells."Cell Cycle 9:4703-4710(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome."J. Proteome Res. 9:6298-6316(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Nek6 mediates human cancer cell transformation and is a potential cancer therapeutic target."Mol. Cancer Res. 8:717-728(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Caught Nek-ing: cilia and centrioles."J. Cell Sci. 118:5161-5169(2005) [PubMed] [Europe PMC] [Abstract]
  18. "A role for Nek6 kinase activity in preventing senescence?"Cell Cycle 10:19-20(2011) [PubMed] [Europe PMC] [Abstract]