Semaphorin 3A (SEMA3A)
[Edit]SEMAL; Hsema-I; Hsema-III; SEMA1; SEMAD; SEMAIII; SemD; Coll-1; Sema Domain,Immunoglobulin Domain(Ig),Transmembrane Domain(TM)and Short Cytoplasmic Domain 3A
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SEMA3A is a member of the semaphorin family and encodes a protein with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimer's disease.The first of the CRMP proteins, CRMP2, was identified as an intracellular messenger required for the growth cone-collapse induced by semaphorin 3A.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPL917Hu01 | Recombinant Semaphorin 3A (SEMA3A) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPL917Hu02 | Recombinant Semaphorin 3A (SEMA3A) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| APL917Hu02 | Active Semaphorin 3A (SEMA3A) | Cell culture; Activity Assays. | |
| APL917Hu01 | Active Semaphorin 3A (SEMA3A) | Cell culture; Activity Assays. | |
| Antibodies | PAL917Hu01 | Polyclonal Antibody to Semaphorin 3A (SEMA3A) | WB; IHC; ICC; IP. |
| LAL917Hu71 | Biotin-Linked Polyclonal Antibody to Semaphorin 3A (SEMA3A) | WB; IHC; ICC. | |
| PAL917Hu02 | Polyclonal Antibody to Semaphorin 3A (SEMA3A) | WB; IHC; ICC; IP. | |
| LAL917Hu72 | Biotin-Linked Monoclonal Antibody to Semaphorin 3A (SEMA3A) | WB; IHC; ICC. | |
| MAL917Hu21 | Monoclonal Antibody to Semaphorin 3A (SEMA3A) | WB,IHC | |
| MAL917Hu22 | Monoclonal Antibody to Semaphorin 3A (SEMA3A) | WB; IHC; ICC; IP. | |
| MAL917Hu23 | Monoclonal Antibody to Semaphorin 3A (SEMA3A) | WB; IHC; ICC; IP. | |
| MAL917Hu24 | Monoclonal Antibody to Semaphorin 3A (SEMA3A) | WB; IHC; ICC; IP. | |
| Assay Kits | SEL917Hu | ELISA Kit for Semaphorin 3A (SEMA3A) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCL917Hu | CLIA Kit for Semaphorin 3A (SEMA3A) | Chemiluminescent immunoassay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPL917Mu01 | Recombinant Semaphorin 3A (SEMA3A) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPL917Mu02 | Recombinant Semaphorin 3A (SEMA3A) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAL917Mu01 | Polyclonal Antibody to Semaphorin 3A (SEMA3A) | WB; IHC; ICC; IP. |
| PAL917Mu02 | Polyclonal Antibody to Semaphorin 3A (SEMA3A) | WB; IHC; ICC; IP. | |
| LAL917Mu71 | Biotin-Linked Polyclonal Antibody to Semaphorin 3A (SEMA3A) | WB; IHC; ICC. | |
| Assay Kits | SEL917Mu | ELISA Kit for Semaphorin 3A (SEMA3A) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPL917Ra01 | Recombinant Semaphorin 3A (SEMA3A) | Positive Control; Immunogen; SDS-PAGE; WB. |
| APL917Ra01 | Active Semaphorin 3A (SEMA3A) | Cell culture; Activity Assays. | |
| Antibodies | PAL917Ra01 | Polyclonal Antibody to Semaphorin 3A (SEMA3A) | WB; IHC; ICC; IP. |
| MAL917Ra21 | Monoclonal Antibody to Semaphorin 3A (SEMA3A) | WB; IHC; ICC; IP. | |
| Assay Kits | SEL917Ra | ELISA Kit for Semaphorin 3A (SEMA3A) | Enzyme-linked immunosorbent assay for Antigen Detection. |
- "The semaphorin genes encode a family of transmembrane and secreted growth cone guidance molecules."Cell 75:1389-1399(1993) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
- "SEMA3A deletion in a family with Kallmann syndrome validates the role of semaphorin 3A in human puberty and olfactory system development."Hum. Reprod. 27:1460-1465(2012) [PubMed] [Europe PMC] [Abstract]
- "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
- "Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma." Nature 469:539-542(2011) [PubMed] [Europe PMC] [Abstract]
- "SEMA3A, a gene involved in axonal pathfinding, is mutated in patients with Kallmann syndrome." PLoS Genet. 8:E1002896-E1002896(2012) [PubMed] [Europe PMC] [Abstract]
- "The prevalence of CHD7 missense versus truncating mutations is higher in patients with Kallmann syndrome than in typical CHARGE patients." J. Clin. Endocrinol. Metab. 99:E2138-2143(2014) [PubMed] [Europe PMC] [Abstract]