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Nei Endonuclease VIII Like Protein 1 (NEIL1)

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NEI1; hFPG1; FPG1; DNA-(apurinic or apyrimidinic site) lyase Neil1; Nei-like protein 1; DNA glycosylase/AP lyase Neil1

Nei Endonuclease VIII Like Protein 1 (NEIL1)
CCC L915
HGNC 18448
MGI 1920024
PubMed 11904416
RGD 1306077
UniProt Q96FI4
Wiki NEIL1
NEIL1 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction.
Bacterial Fpg/Nei proteins contain 2 structural domains: an N-terminal 2-layered beta sandwich and a C-terminal 4-helix bundle, which includes a helix-2-turns-helix (H2TH) motif and a zinc finger. The deduced 390-amino acid human NEIL1 protein has conserved residues in 6 highly conserved regions that span both structural domains of the bacterial Fpg/Nei proteins, but it lacks the characteristic zinc finger motif.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL915Hu01 Recombinant Nei Endonuclease VIII Like Protein 1 (NEIL1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAL915Hu01 Polyclonal Antibody to Nei Endonuclease VIII Like Protein 1 (NEIL1) WB; IHC; ICC; IP.
MAL915Hu21 Monoclonal Antibody to Nei Endonuclease VIII Like Protein 1 (NEIL1) WB; IHC; ICC; IP.
Assay Kits SEL915Hu ELISA Kit for Nei Endonuclease VIII Like Protein 1 (NEIL1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nei Endonuclease VIII Like Protein 1 (NEIL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nei Endonuclease VIII Like Protein 1 (NEIL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nei Endonuclease VIII Like Protein 1 (NEIL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nei Endonuclease VIII Like Protein 1 (NEIL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nei Endonuclease VIII Like Protein 1 (NEIL1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nei Endonuclease VIII Like Protein 1 (NEIL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nei Endonuclease VIII Like Protein 1 (NEIL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nei Endonuclease VIII Like Protein 1 (NEIL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nei Endonuclease VIII Like Protein 1 (NEIL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nei Endonuclease VIII Like Protein 1 (NEIL1) ELISA Kit Customized Service Offer
  1. "A back-up glycosylase in Nth1 knock-out mice is a functional Nei (endonuclease VIII) homologue."J. Biol. Chem. 277:42205-42213(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "A novel human DNA glycosylase that removes oxidative DNA damage and is homologous to Escherichia coli endonuclease VIII."DNA Repair 1:517-529(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Identification and characterization of a human DNA glycosylase for repair of modified bases in oxidatively damaged DNA."Proc. Natl. Acad. Sci. U.S.A. 99:3523-3528(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Repair of oxidized bases in DNA bubble structures by human DNA glycosylases NEIL1 and NEIL2."J. Biol. Chem. 278:49679-49684(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Human NEIL1 localizes with the centrosomes and condensed chromosomes during mitosis."DNA Repair 6:1425-1433(2007) [PubMed] [Europe PMC] [Abstract]
  9. "RNA editing changes the lesion specificity for the DNA repair enzyme NEIL1."Proc. Natl. Acad. Sci. U.S.A. 107:20715-20719(2010) [PubMed] [Europe PMC] [Abstract]
  10. "The crystal structure of human endonuclease VIII-like 1 (NEIL1) reveals a zincless finger motif required for glycosylase activity."Proc. Natl. Acad. Sci. U.S.A. 101:10284-10289(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Exome sequencing identified MYO1E and NEIL1 as candidate genes for human autosomal recessive steroid-resistant nephrotic syndrome." Kidney Int. 80:389-396(2011) [PubMed] [Europe PMC] [Abstract]