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Nei Endonuclease VIII Like Protein 2 (NEIL2)

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NEH2; Endonuclease 8-like 2; DNA glycosylase/AP lyase Neil2; DNA-(apurinic or apyrimidinic site) lyase Neil2; Nei-like protein 2

Nei Endonuclease VIII Like Protein 2 (NEIL2)
CCC L914
HGNC 18956
MGI 2686058
PubMed 16793361
RGD 1312033
UniProt Q969S2
Wiki NEIL2
NEIL2 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction.
Bacterial Fpg/Nei proteins contain 2 structural domains: an N-terminal 2-layered beta sandwich and a C-terminal 4-helix bundle, which includes a helix-2-turns-helix (H2TH) motif and a zinc finger. The deduced 332-amino acid human NEIL2 protein has conserved residues in 6 highly conserved regions that span both structural domains of the bacterial Fpg/Nei proteins, but it has an unusual CHCC zinc finger.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nei Endonuclease VIII Like Protein 2 (NEIL2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nei Endonuclease VIII Like Protein 2 (NEIL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nei Endonuclease VIII Like Protein 2 (NEIL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nei Endonuclease VIII Like Protein 2 (NEIL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nei Endonuclease VIII Like Protein 2 (NEIL2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nei Endonuclease VIII Like Protein 2 (NEIL2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nei Endonuclease VIII Like Protein 2 (NEIL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nei Endonuclease VIII Like Protein 2 (NEIL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nei Endonuclease VIII Like Protein 2 (NEIL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nei Endonuclease VIII Like Protein 2 (NEIL2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nei Endonuclease VIII Like Protein 2 (NEIL2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nei Endonuclease VIII Like Protein 2 (NEIL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nei Endonuclease VIII Like Protein 2 (NEIL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nei Endonuclease VIII Like Protein 2 (NEIL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nei Endonuclease VIII Like Protein 2 (NEIL2) ELISA Kit Customized Service Offer
  1. "A back-up glycosylase in Nth1 knock-out mice is a functional Nei (endonuclease VIII) homologue."J. Biol. Chem. 277:42205-42213(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence and analysis of human chromosome 8." Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Identification and characterization of a novel human DNA glycosylase for repair of cytosine-derived lesions."J. Biol. Chem. 277:30417-30420(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Repair of oxidized bases in DNA bubble structures by human DNA glycosylases NEIL1 and NEIL2."J. Biol. Chem. 278:49679-49684(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Acetylation of the human DNA glycosylase NEIL2 and inhibition of its activity."Nucleic Acids Res. 32:3033-3039(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Identification of a zinc finger domain in the human NEIL2 (Nei-like-2) protein."J. Biol. Chem. 279:47132-47138(2004) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]