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N-Deacetylase/N-Sulfotransferase 2 (NDST2)

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HSST2; NCST2; NST2; Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2; Glucosaminyl N-deacetylase/N-sulfotransferase 2; N-heparan sulfate sulfotransferase 2

N-Deacetylase/N-Sulfotransferase 2 (NDST2)
CCC L909
HGNC 7681
MGI 97040
PubMed 22298785
RGD 1304700
UniProt P52849
Wiki NDST2
The initial step in the processing of heparan polymers to heparan sulfate or heparin is N-deacetylation/N-sulfation. This step is catalyzed by heparan N-deacetylase/N-sulfotransferases. The predicted 883-amino acid protein is 70% similar to NDST1. Analysis of genomic clones revealed that the NDST2 gene contains 13 exons spanning 6.5 kb. The 12 introns that interrupt the coding region occur at similar sites within the coding sequence of NDST1.
Mast cells developed from the bone marrow of the Ndst2 -/- mice contained high levels of various protease transcripts and had substantial amounts of mast-cell protease-6 protein in their granules. However, they failed to express mast-cell protease-5 and mast-cell carboxypeptidase A.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant N-Deacetylase/N-Sulfotransferase 2 (NDST2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to N-Deacetylase/N-Sulfotransferase 2 (NDST2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to N-Deacetylase/N-Sulfotransferase 2 (NDST2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for N-Deacetylase/N-Sulfotransferase 2 (NDST2) CLIA Kit Customized Service Offer
n/a ELISA Kit for N-Deacetylase/N-Sulfotransferase 2 (NDST2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant N-Deacetylase/N-Sulfotransferase 2 (NDST2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to N-Deacetylase/N-Sulfotransferase 2 (NDST2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to N-Deacetylase/N-Sulfotransferase 2 (NDST2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for N-Deacetylase/N-Sulfotransferase 2 (NDST2) CLIA Kit Customized Service Offer
n/a ELISA Kit for N-Deacetylase/N-Sulfotransferase 2 (NDST2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant N-Deacetylase/N-Sulfotransferase 2 (NDST2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to N-Deacetylase/N-Sulfotransferase 2 (NDST2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to N-Deacetylase/N-Sulfotransferase 2 (NDST2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for N-Deacetylase/N-Sulfotransferase 2 (NDST2) CLIA Kit Customized Service Offer
n/a ELISA Kit for N-Deacetylase/N-Sulfotransferase 2 (NDST2) ELISA Kit Customized Service Offer
  1. "cDNA cloning, genomic organization and chromosomal localization of human heparan glucosaminyl N-deacetylase/N-sulphotransferase-2."Biochem. J. 332:303-307(1998) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Overexpression of different isoforms of glucosaminyl N-deacetylase/N-sulfotransferase results in distinct heparan sulfate N-sulfation patterns."Biochemistry 39:4552-4558(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Antibody-based assay for N-deacetylase activity of heparan sulfate/heparin N-deacetylase/N-sulfotransferase (NDST): novel characteristics of NDST-1 and -2."Glycobiology 13:1-10(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Characterization of the N-deacetylase domain from the heparan sulfate N-deacetylase/N-sulfotransferase 2."Biochem. Biophys. Res. Commun. 339:1232-1237(2006) [PubMed] [Europe PMC] [Abstract]