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Nuclear Distribution Protein NudE Like Protein 1 (NDEL1)

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EOPA; MITAP1; NUDEL; Mitosin-associated protein 1

Nuclear Distribution Protein NudE Like Protein 1 (NDEL1)
CCC L906
HGNC 17620
MGI 1932915
PubMed 17060449
RGD 621235
UniProt Q9GZM8
Wiki NDEL1
NDEL1 encodes a thiol-activated peptidase that is phosphorylated in M phase of the cell cycle. Phosphorylation regulates the cell cycle-dependent distribution of this protein, with a fraction of the protein bound strongly to centrosomes in interphase and localized to mitotic spindles in early M phase. Overall, this protein plays a role in nervous system development. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.Overexpression of mouse Lis1 in COS-7 cells caused a redistribution of transfected NUDEL. Biochemical and mutation analyses revealed that NUDEL is phosphorylated on 3 sites by CDK5. Overexpression of a phosphorylation-minus NUDEL mutant or inhibition of CDK5 produced neuritic swellings in rat brain cortical neurons.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nuclear Distribution Protein NudE Like Protein 1 (NDEL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nuclear Distribution Protein NudE Like Protein 1 (NDEL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nuclear Distribution Protein NudE Like Protein 1 (NDEL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nuclear Distribution Protein NudE Like Protein 1 (NDEL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nuclear Distribution Protein NudE Like Protein 1 (NDEL1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nuclear Distribution Protein NudE Like Protein 1 (NDEL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nuclear Distribution Protein NudE Like Protein 1 (NDEL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nuclear Distribution Protein NudE Like Protein 1 (NDEL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nuclear Distribution Protein NudE Like Protein 1 (NDEL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nuclear Distribution Protein NudE Like Protein 1 (NDEL1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nuclear Distribution Protein NudE Like Protein 1 (NDEL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nuclear Distribution Protein NudE Like Protein 1 (NDEL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nuclear Distribution Protein NudE Like Protein 1 (NDEL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nuclear Distribution Protein NudE Like Protein 1 (NDEL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nuclear Distribution Protein NudE Like Protein 1 (NDEL1) ELISA Kit Customized Service Offer
  1. "NUDEL is a novel cdk5 substrate that associates with LIS1 and cytoplasmic dynein."Neuron 28:697-711(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Human Nudel and NudE as regulators of cytoplasmic dynein in poleward protein transport along the mitotic spindle."Mol. Cell. Biol. 23:1239-1250(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Inhibition of NUDEL (nuclear distribution element-like)-oligopeptidase activity by disrupted-in-schizophrenia 1."Proc. Natl. Acad. Sci. U.S.A. 102:3828-3833(2005) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation."Hum. Mol. Genet. 12:1591-1608(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth."Proc. Natl. Acad. Sci. U.S.A. 100:289-294(2003) [PubMed] [Europe PMC] [Abstract]
  10. ErratumProc. Natl. Acad. Sci. U.S.A. 101:13969-13969(2004)
  11. "Nudel functions in membrane traffic mainly through association with Lis1 and cytoplasmic dynein."J. Cell Biol. 164:557-566(2004) [PubMed] [Europe PMC] [Abstract]
  12. "Disrupted in Schizophrenia 1 and Nudel form a neurodevelopmentally regulated protein complex: implications for schizophrenia and other major neurological disorders."Mol. Cell. Neurosci. 25:42-55(2004) [PubMed] [Europe PMC] [Abstract]
  13. "Coupling PAF signaling to dynein regulation: structure of LIS1 in complex with PAF-acetylhydrolase."Neuron 44:809-821(2004) [PubMed] [Europe PMC] [Abstract]
  14. "Cloning and characterization of the human and rabbit NUDEL-oligopeptidase promoters and their negative regulation."Biochim. Biophys. Acta 1730:77-84(2005) [PubMed] [Europe PMC] [Abstract]
  15. "Recruitment of katanin p60 by phosphorylated NDEL1, an LIS1 interacting protein, is essential for mitotic cell division and neuronal migration."Hum. Mol. Genet. 14:3113-3128(2005) [PubMed] [Europe PMC] [Abstract]
  16. "DISC1-NDEL1/NUDEL protein interaction, an essential component for neurite outgrowth, is modulated by genetic variations of DISC1."Hum. Mol. Genet. 15:3313-3323(2006) [PubMed] [Europe PMC] [Abstract]
  17. "Nudel contributes to microtubule anchoring at the mother centriole and is involved in both dynein-dependent and -independent centrosomal protein assembly."Mol. Biol. Cell 17:680-689(2006) [PubMed] [Europe PMC] [Abstract]
  18. "Centrosomal proteins Nde1 and Su48 form a complex regulated by phosphorylation."Oncogene 25:6048-6055(2006) [PubMed] [Europe PMC] [Abstract]
  19. "Cenp-F links kinetochores to Ndel1/Nde1/Lis1/dynein microtubule motor complexes."Curr. Biol. 17:1173-1179(2007) [PubMed] [Europe PMC] [Abstract]
  20. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  21. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  22. "Ndel1 palmitoylation: a new mean to regulate cytoplasmic dynein activity."EMBO J. 29:107-119(2010) [PubMed] [Europe PMC] [Abstract]
  23. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]