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Nuclear Distribution Protein NudE Homolog 1 (NDE1)

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NUDE; NUDE1

Nuclear Distribution Protein NudE Homolog 1 (NDE1)
CCC L905
HGNC 17619
MGI 1914453
PubMed 23704059
RGD 620038
UniProt Q9NXR1
Wiki NDE1
NDE1 encodes a member of the nuclear distribution E (NudE) family of proteins. The encoded protein is localized at the centrosome and interacts with other centrosome components as part of a multiprotein complex that regulates dynein function. This protein plays an essential role in microtubule organization, mitosis and neuronal migration. Alternative splicing results in multiple transcript variants.
The deduced 344-amino acid protein contains an asp- and glu-rich N-terminal half and a ser- and thr-rich C-terminal half. Rat Nude shares significant homology with a fungal nuclear distribution protein, NudE, and a Xenopus mitotic phosphoprotein, Mpp43. Northern blot analysis detected a 2.4-kb Nude transcript in all rat tissues examined.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nuclear Distribution Protein NudE Homolog 1 (NDE1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nuclear Distribution Protein NudE Homolog 1 (NDE1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nuclear Distribution Protein NudE Homolog 1 (NDE1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nuclear Distribution Protein NudE Homolog 1 (NDE1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nuclear Distribution Protein NudE Homolog 1 (NDE1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nuclear Distribution Protein NudE Homolog 1 (NDE1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nuclear Distribution Protein NudE Homolog 1 (NDE1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nuclear Distribution Protein NudE Homolog 1 (NDE1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nuclear Distribution Protein NudE Homolog 1 (NDE1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nuclear Distribution Protein NudE Homolog 1 (NDE1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nuclear Distribution Protein NudE Homolog 1 (NDE1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nuclear Distribution Protein NudE Homolog 1 (NDE1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nuclear Distribution Protein NudE Homolog 1 (NDE1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nuclear Distribution Protein NudE Homolog 1 (NDE1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nuclear Distribution Protein NudE Homolog 1 (NDE1) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Human Nudel and NudE as regulators of cytoplasmic dynein in poleward protein transport along the mitotic spindle."Mol. Cell. Biol. 23:1239-1250(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Nudel contributes to microtubule anchoring at the mother centriole and is involved in both dynein-dependent and -independent centrosomal protein assembly."Mol. Biol. Cell 17:680-689(2006) [PubMed] [Europe PMC] [Abstract]
  6. "Centrosomal proteins Nde1 and Su48 form a complex regulated by phosphorylation."Oncogene 25:6048-6055(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Cenp-F links kinetochores to Ndel1/Nde1/Lis1/dynein microtubule motor complexes."Curr. Biol. 17:1173-1179(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Ndel1 palmitoylation: a new mean to regulate cytoplasmic dynein activity."EMBO J. 29:107-119(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "The essential role of centrosomal NDE1 in human cerebral cortex neurogenesis." Am. J. Hum. Genet. 88:523-535(2011) [PubMed] [Europe PMC] [Abstract]
  13. "Human mutations in NDE1 cause extreme microcephaly with lissencephaly."Am. J. Hum. Genet. 88:536-547(2011) [PubMed] [Europe PMC] [Abstract]
  14. ErratumAm. J. Hum. Genet. 88:677-677(2011)
  15. "Novel NDE1 homozygous mutation resulting in microhydranencephaly and not microlyssencephaly."Neurogenetics 13:189-194(2012) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]