≡

NGFI-A Binding Protein 1 (NAB1)

[Edit]

EGR1 binding protein 1; Transcriptional regulatory protein p54

NGFI-A Binding Protein 1 (NAB1)
CCC L901
HGNC 7626
MGI 107564
PubMed 16025126
RGD 70882
UniProt Q13506
Wiki NAB1
NAB1 binds the inhibitory domain of NGFIA and inhibits the ability of NGFIA to activate transcription. NAB1 also represses Krox20 activity, but it does not influence Egr3 or NGFIC, thus providing a mechanism for the differential regulation of this family of immediate-early transcription factors.
Nab1 was expressed in the nuclei of mouse cardiac myocytes, endothelial cells, and fibroblasts. Pressure overload induced by transverse aortic constriction increased Nab1 expression in the left ventricular myocardium. NAB1 expression was increased about 2.5-fold in left ventricles from failing human hearts compared with nonfailing hearts.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant NGFI-A Binding Protein 1 (NAB1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to NGFI-A Binding Protein 1 (NAB1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to NGFI-A Binding Protein 1 (NAB1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for NGFI-A Binding Protein 1 (NAB1) CLIA Kit Customized Service Offer
n/a ELISA Kit for NGFI-A Binding Protein 1 (NAB1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant NGFI-A Binding Protein 1 (NAB1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to NGFI-A Binding Protein 1 (NAB1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to NGFI-A Binding Protein 1 (NAB1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for NGFI-A Binding Protein 1 (NAB1) CLIA Kit Customized Service Offer
n/a ELISA Kit for NGFI-A Binding Protein 1 (NAB1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant NGFI-A Binding Protein 1 (NAB1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to NGFI-A Binding Protein 1 (NAB1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to NGFI-A Binding Protein 1 (NAB1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for NGFI-A Binding Protein 1 (NAB1) CLIA Kit Customized Service Offer
n/a ELISA Kit for NGFI-A Binding Protein 1 (NAB1) ELISA Kit Customized Service Offer
  1. "NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli."Mol. Cell. Biol. 16:3545-3553(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The transcription factor Krox20 is an E3 ligase that sumoylates its Nab coregulators."EMBO Rep. 12:1018-1023(2011) [PubMed] [Europe PMC] [Abstract]
  6. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  7. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  8. "Solution structure of the NCD2 domain in human transcriptional repressor NAB1 protein."Submitted (APR-2008) to the PDB data bank