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Ubiquitin Associated And SH3 Domain Containing Protein A (UBASH3A)

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STS-2; TULA; CLIP4; T-cell ubiquitin ligand 1; Cbl-interacting protein 4; Suppressor of T-cell receptor signaling 2

Ubiquitin Associated And SH3 Domain Containing Protein A (UBASH3A)
CCC L895
HGNC 12462
MGI 1926074
PubMed 11281453
RGD 1310305
UniProt P57075
Wiki UBASH3A
The deduced 661-amino acid UBASH3A protein contains a ubiquitin-associated (UBA) domain, an SH3 domain, and a novel domain, designated HCD, that shows homology to hypothetical proteins from C. elegans and Drosophila. The HCD domain contains a strong potential nuclear localization signal. The authors stated that this was the first reported protein containing both UBA and SH3 domains. They found the highest expression of UBASH3A in tissues belonging to the immune system, including spleen, peripheral blood leukocytes, and bone marrow.
Northern and Western blot analyses showed that expression of Sts1 was ubiquitous, whereas expression of Sts2 was restricted to T cells in thymus, spleen, and bone marrow.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Associated And SH3 Domain Containing Protein A (UBASH3A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Associated And SH3 Domain Containing Protein A (UBASH3A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Associated And SH3 Domain Containing Protein A (UBASH3A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Associated And SH3 Domain Containing Protein A (UBASH3A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Associated And SH3 Domain Containing Protein A (UBASH3A) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Associated And SH3 Domain Containing Protein A (UBASH3A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Associated And SH3 Domain Containing Protein A (UBASH3A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Associated And SH3 Domain Containing Protein A (UBASH3A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Associated And SH3 Domain Containing Protein A (UBASH3A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Associated And SH3 Domain Containing Protein A (UBASH3A) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Associated And SH3 Domain Containing Protein A (UBASH3A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Associated And SH3 Domain Containing Protein A (UBASH3A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Associated And SH3 Domain Containing Protein A (UBASH3A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Associated And SH3 Domain Containing Protein A (UBASH3A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Associated And SH3 Domain Containing Protein A (UBASH3A) ELISA Kit Customized Service Offer
  1. "Isolation and characterization of the UBASH3A gene on 21q22.3 encoding a potential nuclear protein with a novel combination of domains."Hum. Genet. 108:140-147(2001) [PubMed] [Europe PMC] [Abstract]
  2. "TULA: an SH3- and UBA-containing protein that binds to c-Cbl and ubiquitin."Oncogene 23:4690-4706(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of human chromosome 21." Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases."J. Biol. Chem. 279:32786-32795(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The Cbl-interacting protein TULA inhibits dynamin-dependent endocytosis."Exp. Cell Res. 313:1696-1709(2007) [PubMed] [Europe PMC] [Abstract]
  7. "TULA proteins regulate activity of the protein tyrosine kinase Syk."J. Cell. Biochem. 104:953-964(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Solution structure of the UBA domain of human UBASH3A protein."Submitted (NOV-2005) to the PDB data bank