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Ubiquitin Fusion Degradation 1 Like Protein (UFD1L)

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UFD1

Ubiquitin Fusion Degradation 1 Like Protein (UFD1L)
CCC L890
HGNC 12520
MGI 109353
PubMed 11574150
RGD 619822
UniProt Q92890
Wiki UFD1L
UFD1L forms a complex with two other proteins, NPL4 and VCP, that is necessary for the degradation of ubiquitinated proteins. In addition, this complex controls the disassembly of the mitotic spindle and the formation of a closed nuclear envelope after mitosis. Mutations in this gene have been associated with Catch 22 syndrome as well as cardiac and craniofacial defects. Alternative splicing results in multiple transcript variants encoding different isoforms.
Symbolized UFD1L by them, the gene encodes the human homolog of the yeast ubiquitin fusion degradation 1 (UFD1) protein that is involved in the degradation of ubiquitin fusion proteins. Cloning and characterization of the murine homolog (Ufd1l) showed it to be expressed during embryogenesis in the eyes and in the inner ear primordia.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Fusion Degradation 1 Like Protein (UFD1L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Fusion Degradation 1 Like Protein (UFD1L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Fusion Degradation 1 Like Protein (UFD1L) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Fusion Degradation 1 Like Protein (UFD1L) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Fusion Degradation 1 Like Protein (UFD1L) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Fusion Degradation 1 Like Protein (UFD1L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Fusion Degradation 1 Like Protein (UFD1L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Fusion Degradation 1 Like Protein (UFD1L) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Fusion Degradation 1 Like Protein (UFD1L) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Fusion Degradation 1 Like Protein (UFD1L) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Fusion Degradation 1 Like Protein (UFD1L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Fusion Degradation 1 Like Protein (UFD1L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Fusion Degradation 1 Like Protein (UFD1L) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Fusion Degradation 1 Like Protein (UFD1L) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Fusion Degradation 1 Like Protein (UFD1L) ELISA Kit Customized Service Offer
  1. "UFD1L, a developmentally expressed ubiquitination gene, is deleted in CATCH 22 syndrome."Hum. Mol. Genet. 6:259-265(1997) [PubMed] [Europe PMC] [Abstract]
  2. "A genome annotation-driven approach to cloning the human ORFeome."Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of human chromosome 22." Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Cloning and characterization of the gene encoding human NPL4, a protein interacting with the ubiquitin fusion-degradation protein (UFD1L)."Gene 275:39-46(2001) [PubMed] [Europe PMC] [Abstract]
  6. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "Ubiquitin-recognition protein Ufd1 couples the endoplasmic reticulum (ER) stress response to cell cycle control."Proc. Natl. Acad. Sci. U.S.A. 108:9119-9124(2011) [PubMed] [Europe PMC] [Abstract]
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  13. "Solution structure of human ubiquitin fusion degradation protein 1 homolog UFD1."Submitted (APR-2008) to the PDB data bank