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Ubiquitin Like Containing PHD And Ring Finger Domains Protein 2 (UHRF2)

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NIRF; RNF107; URF2; Np95/ICBP90-like RING finger protein; E3 ubiquitin-protein ligase UHRF2; Nuclear zinc finger protein Np97; RING finger protein 107

Ubiquitin Like Containing PHD And Ring Finger Domains Protein 2 (UHRF2)
CCC L888
HGNC 12557
MGI 1923718
PubMed 23404503
RGD 1309990
UniProt Q96PU4
Wiki UHRF2
UHRF2 encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis.
In the SRA-DNA complex, the 5-methylcytosine was flipped out of the duplex DNA and interacted with a binding pocket of the SRA domain. Two loops in the SRA domain reached through the resulting gap in the DNA from both the major and minor grooves to read the other 3 bases of the CpG duplex. The major groove loop appeared to confer both specificity for the CpG dinucleotide and discrimination against methylation of deoxycytidine of the complementary strand.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Like Containing PHD And Ring Finger Domains Protein 2 (UHRF2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Like Containing PHD And Ring Finger Domains Protein 2 (UHRF2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Like Containing PHD And Ring Finger Domains Protein 2 (UHRF2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Like Containing PHD And Ring Finger Domains Protein 2 (UHRF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Like Containing PHD And Ring Finger Domains Protein 2 (UHRF2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Like Containing PHD And Ring Finger Domains Protein 2 (UHRF2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Like Containing PHD And Ring Finger Domains Protein 2 (UHRF2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Like Containing PHD And Ring Finger Domains Protein 2 (UHRF2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Like Containing PHD And Ring Finger Domains Protein 2 (UHRF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Like Containing PHD And Ring Finger Domains Protein 2 (UHRF2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Like Containing PHD And Ring Finger Domains Protein 2 (UHRF2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Like Containing PHD And Ring Finger Domains Protein 2 (UHRF2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Like Containing PHD And Ring Finger Domains Protein 2 (UHRF2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Like Containing PHD And Ring Finger Domains Protein 2 (UHRF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Like Containing PHD And Ring Finger Domains Protein 2 (UHRF2) ELISA Kit Customized Service Offer
  1. "NIRF, a novel RING finger protein, is involved in cell-cycle regulation."Biochem. Biophys. Res. Commun. 296:530-536(2002) [PubMed] [Europe PMC] [Abstract]
  2. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "NIRF induces G1 arrest and associates with Cdk2."Biochem. Biophys. Res. Commun. 319:464-468(2004) [PubMed] [Europe PMC] [Abstract]
  6. "NIRF is a ubiquitin ligase that is capable of ubiquitinating PCNP, a PEST-containing nuclear protein."FEBS Lett. 557:209-214(2004) [PubMed] [Europe PMC] [Abstract]
  7. "ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain."Oncogene 23:7601-7610(2004) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressor."Cell Cycle 10:3284-3299(2011) [PubMed] [Europe PMC] [Abstract]
  11. "UHRF2, a ubiquitin E3 ligase, acts as a small ubiquitin-like modifier E3 ligase for zinc finger protein 131."J. Biol. Chem. 288:9102-9111(2013) [PubMed] [Europe PMC] [Abstract]
  12. "Solution structure of the N-terminal ubiquitin-like domain in human NP95/ICBP90-like RING finger protein (NIRF)."Submitted (AUG-2005) to the PDB data bank
  13. "2.1 Angstrom crystal structure of the human ubiquitin ligase NIRF."Submitted (JAN-2006) to the PDB data bank
  14. "2.1 Angstrom crystal structure of the human ubiquitin ligase NIRF."Submitted (FEB-2009) to the PDB data bank
  15. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]