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Ubiquitin Like Containing PHD And Ring Finger Domains Protein 1 (UHRF1)

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ICBP90; Np95; RNF106; Inverted CCAAT box-binding protein of 90 kDa; Nuclear zinc finger protein Np95; RING finger protein 106; Transcription factor ICBP90

Ubiquitin Like Containing PHD And Ring Finger Domains Protein 1 (UHRF1)
CCC L887
HGNC 12556
MGI 1338889
PubMed 22330138
RGD 1595855
UniProt Q96T88
Wiki UHRF1
UHRF1 encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase II alpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. Multiple transcript variants encoding different isoforms have been found for this gene.The protein has a calculated molecular mass of about 90 kD. ICBP90 contains an N-terminal ubiquitin-like domain partially overlapped by a leucine zipper domain, followed by a central zinc finger of the PHD finger type and a C-terminal zinc finger of the ring finger type.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Like Containing PHD And Ring Finger Domains Protein 1 (UHRF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Like Containing PHD And Ring Finger Domains Protein 1 (UHRF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Like Containing PHD And Ring Finger Domains Protein 1 (UHRF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Like Containing PHD And Ring Finger Domains Protein 1 (UHRF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Like Containing PHD And Ring Finger Domains Protein 1 (UHRF1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Like Containing PHD And Ring Finger Domains Protein 1 (UHRF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Like Containing PHD And Ring Finger Domains Protein 1 (UHRF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Like Containing PHD And Ring Finger Domains Protein 1 (UHRF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Like Containing PHD And Ring Finger Domains Protein 1 (UHRF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Like Containing PHD And Ring Finger Domains Protein 1 (UHRF1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Like Containing PHD And Ring Finger Domains Protein 1 (UHRF1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Like Containing PHD And Ring Finger Domains Protein 1 (UHRF1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Like Containing PHD And Ring Finger Domains Protein 1 (UHRF1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Like Containing PHD And Ring Finger Domains Protein 1 (UHRF1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Like Containing PHD And Ring Finger Domains Protein 1 (UHRF1) ELISA Kit Customized Service Offer
  1. "ICBP90, a novel human CCAAT binding protein, involved in the regulation of topoisomerase IIa expression."Cancer Res. 60:121-128(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Isolation and characterization of a novel human radiosusceptibility gene, NP95."Radiat. Res. 166:723-733(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "ICBP90 belongs to a new family of proteins with an expression that is deregulated in cancer cells."Br. J. Cancer 89:120-127(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Phosphorylation of ICBP90 by protein kinase A enhances topoisomerase IIalpha expression."Biochem. Biophys. Res. Commun. 319:590-595(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Down-regulation of nuclear protein ICBP90 by p53/p21Cip1/WAF1-dependent DNA-damage checkpoint signals contributes to cell cycle arrest at G1/S transition."Genes Cells 9:131-142(2004) [PubMed] [Europe PMC] [Abstract]
  10. "ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain."Oncogene 23:7601-7610(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  12. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  13. "Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry."Proteomics 7:868-874(2007) [PubMed] [Europe PMC] [Abstract]
  14. "UHRF1 plays a role in maintaining DNA methylation in mammalian cells."Science 317:1760-1764(2007) [PubMed] [Europe PMC] [Abstract]
  15. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  16. "ICBP90, a novel methyl K9 H3 binding protein linking protein ubiquitination with heterochromatin formation."Mol. Cell. Biol. 28:705-717(2008) [PubMed] [Europe PMC] [Abstract]
  17. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  18. "UHRF1 is a novel molecular marker for diagnosis and the prognosis of bladder cancer."Br. J. Cancer 101:98-105(2009) [PubMed] [Europe PMC] [Abstract]
  19. "UHRF1 binds G9a and participates in p21 transcriptional regulation in mammalian cells."Nucleic Acids Res. 37:493-505(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  21. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  22. "The multi-domain protein Np95 connects DNA methylation and histone modification."Nucleic Acids Res. 38:1796-1804(2010) [PubMed] [Europe PMC] [Abstract]
  23. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  24. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  25. "The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1."Nucleic Acids Res. 39:8355-8365(2011) [PubMed] [Europe PMC] [Abstract]
  26. "Recognition of 5-hydroxymethylcytosine by the Uhrf1 SRA domain."PLoS ONE 6:E21306-E21306(2011) [PubMed] [Europe PMC] [Abstract]
  27. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  28. "The epigenetic regulator UHRF1 promotes ubiquitination-mediated degradation of the tumor-suppressor protein promyelocytic leukemia protein."Oncogene 32:3819-3828(2013) [PubMed] [Europe PMC] [Abstract]
  29. "UHRF1 coordinates peroxisome proliferator activated receptor gamma (PPARG) epigenetic silencing and mediates colorectal cancer progression."Oncogene 31:5061-5072(2012) [PubMed] [Europe PMC] [Abstract]
  30. "The SRA protein UHRF1 promotes epigenetic crosstalks and is involved in prostate cancer progression."Oncogene 31:4878-4887(2012) [PubMed] [Europe PMC] [Abstract]
  31. "M phase phosphorylation of the epigenetic regulator UHRF1 regulates its physical association with the deubiquitylase USP7 and stability."Proc. Natl. Acad. Sci. U.S.A. 109:4828-4833(2012) [PubMed] [Europe PMC] [Abstract]
  32. "Ubiquitin-like domain of human nuclear zinc finger protein NP95."Submitted (JAN-2006) to the PDB data bank
  33. "Expression, purification, crystallization and preliminary crystallographic study of the SRA domain of the human UHRF1 protein."Acta Crystallogr. F 64:922-925(2008) [PubMed] [Europe PMC] [Abstract]
  34. "Structure and hemimethylated CpG binding of the SRA domain from human UHRF1."J. Biol. Chem. 283:34490-34494(2008) [PubMed] [Europe PMC] [Abstract]
  35. "Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1."Nature 455:822-825(2008) [PubMed] [Europe PMC] [Abstract]
  36. "Crystal structure of PHD domain of UHRF1 and insights into recognition of unmodified histone H3 arginine residue 2."Cell Res. 21:1374-1378(2011) [PubMed] [Europe PMC] [Abstract]
  37. "Structural basis for site-specific reading of unmodified R2 of histone H3 tail by UHRF1 PHD finger."Cell Res. 21:1379-1382(2011) [PubMed] [Europe PMC] [Abstract]
  38. "Recognition of multivalent histone states associated with heterochromatin by UHRF1 protein."J. Biol. Chem. 286:24300-24311(2011) [PubMed] [Europe PMC] [Abstract]
  39. "PHD finger recognition of unmodified histone H3R2 links UHRF1 to regulation of euchromatic gene expression."Mol. Cell 43:275-284(2011) [PubMed] [Europe PMC] [Abstract]
  40. "The PHD finger of human UHRF1 reveals a new subgroup of unmethylated histone H3 tail readers."PLoS ONE 6:E27599-E27599(2011) [PubMed] [Europe PMC] [Abstract]
  41. "UHRF1 double tudor domain and the adjacent PHD finger act together to recognize K9me3-containing histone H3 tail."J. Mol. Biol. 415:318-328(2012) [PubMed] [Europe PMC] [Abstract]
  42. "Recognition of modification status on a histone H3 tail by linked histone reader modules of the epigenetic regulator UHRF1."Proc. Natl. Acad. Sci. U.S.A. 109:12950-12955(2012) [PubMed] [Europe PMC] [Abstract]