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Regulator Of Nonsense Transcripts 3A (RENT3A)

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UPF3A; HUPF3A; UPF3; Nonsense mRNA reducing factor 3A; Up-frameshift suppressor 3 homolog A

Regulator Of Nonsense Transcripts 3A (RENT3A)
CCC L878
HGNC 20332
MGI 1914281
PubMed 11163187
RGD 1308778
UniProt Q9H1J1
Wiki UPF3A
UPF3A encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. Two splice variants encoding different isoforms have been found for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Regulator Of Nonsense Transcripts 3A (RENT3A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Regulator Of Nonsense Transcripts 3A (RENT3A) Monoclonal Antibody Customized Service Offer
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n/a ELISA Kit for Regulator Of Nonsense Transcripts 3A (RENT3A) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Regulator Of Nonsense Transcripts 3A (RENT3A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Regulator Of Nonsense Transcripts 3A (RENT3A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Regulator Of Nonsense Transcripts 3A (RENT3A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Regulator Of Nonsense Transcripts 3A (RENT3A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Regulator Of Nonsense Transcripts 3A (RENT3A) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Regulator Of Nonsense Transcripts 3A (RENT3A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Regulator Of Nonsense Transcripts 3A (RENT3A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Regulator Of Nonsense Transcripts 3A (RENT3A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Regulator Of Nonsense Transcripts 3A (RENT3A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Regulator Of Nonsense Transcripts 3A (RENT3A) ELISA Kit Customized Service Offer
  1. "Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon."Cell 103:1121-1131(2000) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and analysis of human chromosome 13." Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4)."Mol. Cell. Biol. 21:209-223(2001) [PubMed] [Europe PMC] [Abstract]
  5. "Role of the nonsense-mediated decay factor hUpf3 in the splicing-dependent exon-exon junction complex."Science 293:1832-1836(2001) [PubMed] [Europe PMC] [Abstract]
  6. "Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1."Science 293:1836-1839(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Characterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1."RNA 9:77-87(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translation."RNA 12:1015-1022(2006) [PubMed] [Europe PMC] [Abstract]
  9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  10. "Solution NMR structure of nonsense mRNA reducing factor 3A from H. sapiens, northeast structural genomics consortium target HR4714B."Submitted (AUG-2010) to the PDB data bank