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Regulator Of Nonsense Transcripts 2 (RENT2)

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UPF2; HUPF2; smg3; Nonsense mRNA reducing factor 2; Up-frameshift suppressor 2 homolog

Regulator Of Nonsense Transcripts 2 (RENT2)
CCC L877
HGNC 17854
MGI 2449307
RGD 1309178
UniProt Q9HAU5
RENT2 encodes a protein that is part of a post-splicing multiprotein complex, the exon junction complex, involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons.
This protein is located in the perinuclear area. It interacts with translation release factors and the proteins that are functional homologs of yeast Upf1p and Upf3p. Two splice variants have been found for this gene; both variants encode the same protein.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Regulator Of Nonsense Transcripts 2 (RENT2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Regulator Of Nonsense Transcripts 2 (RENT2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Regulator Of Nonsense Transcripts 2 (RENT2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Regulator Of Nonsense Transcripts 2 (RENT2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Regulator Of Nonsense Transcripts 2 (RENT2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Regulator Of Nonsense Transcripts 2 (RENT2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Regulator Of Nonsense Transcripts 2 (RENT2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Regulator Of Nonsense Transcripts 2 (RENT2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Regulator Of Nonsense Transcripts 2 (RENT2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Regulator Of Nonsense Transcripts 2 (RENT2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Regulator Of Nonsense Transcripts 2 (RENT2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Regulator Of Nonsense Transcripts 2 (RENT2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Regulator Of Nonsense Transcripts 2 (RENT2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Regulator Of Nonsense Transcripts 2 (RENT2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Regulator Of Nonsense Transcripts 2 (RENT2) ELISA Kit Customized Service Offer
  1. "Novel Upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexes."Mol. Cell. Biol. 20:8944-8957(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon."Cell 103:1121-1131(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4)."Mol. Cell. Biol. 21:209-223(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay."Genes Dev. 15:2215-2228(2001) [PubMed] [Europe PMC] [Abstract]
  10. "Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1."Science 293:1836-1839(2001) [PubMed] [Europe PMC] [Abstract]
  11. "Characterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1."RNA 9:77-87(2003) [PubMed] [Europe PMC] [Abstract]
  12. "Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements."Mol. Cell 20:65-75(2005) [PubMed] [Europe PMC] [Abstract]
  13. "Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay."Genes Dev. 20:355-367(2006) [PubMed] [Europe PMC] [Abstract]
  14. "NMD factors UPF2 and UPF3 bridge UPF1 to the exon junction complex and stimulate its RNA helicase activity."Nat. Struct. Mol. Biol. 15:85-93(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  16. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  17. "The structural basis for the interaction between nonsense-mediated mRNA decay factors UPF2 and UPF3."Nat. Struct. Mol. Biol. 11:330-337(2004) [PubMed] [Europe PMC] [Abstract]
  18. "Unusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2."EMBO J. 28:2293-2306(2009) [PubMed] [Europe PMC] [Abstract]