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Regulator Of Nonsense Transcripts 1 (RENT1)

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UPF1; HUPF1; NORF1; RENT1; pNORF1; UP Frameshift 1; ATP-dependent helicase RENT1; Nonsense mRNA reducing factor 1; Up-frameshift suppressor 1 homolog

Regulator Of Nonsense Transcripts 1 (RENT1)
CCC L876
HGNC 9962
MGI 107995
PubMed 8855285
UniProt Q92900
Wiki UPF1
This gene encodes a protein that is part of a post-splicing multiprotein complex, the exon junction complex, involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene.HUPF1 encodes a predicted 1,118-amino acid protein. On Western blots of human cell extracts, HUPF1 migrated as a 130-kD protein.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Regulator Of Nonsense Transcripts 1 (RENT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Regulator Of Nonsense Transcripts 1 (RENT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Regulator Of Nonsense Transcripts 1 (RENT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Regulator Of Nonsense Transcripts 1 (RENT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Regulator Of Nonsense Transcripts 1 (RENT1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Regulator Of Nonsense Transcripts 1 (RENT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Regulator Of Nonsense Transcripts 1 (RENT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Regulator Of Nonsense Transcripts 1 (RENT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Regulator Of Nonsense Transcripts 1 (RENT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Regulator Of Nonsense Transcripts 1 (RENT1) ELISA Kit Customized Service Offer
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  2. "Cloning and characterization of HUPF1, a human homolog of the Saccharomyces cerevisiae nonsense mRNA-reducing UPF1 protein."Nucleic Acids Res. 25:814-821(1997) [PubMed] [Europe PMC] [Abstract]
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  4. "SMG-2 is a phosphorylated protein required for mRNA surveillance in Caenorhabditis elegans and related to Upf1p of yeast."Mol. Cell. Biol. 19:5943-5951(1999) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon."Cell 103:1121-1131(2000) [PubMed] [Europe PMC] [Abstract]
  8. "Novel Upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexes."Mol. Cell. Biol. 20:8944-8957(2000) [PubMed] [Europe PMC] [Abstract]
  9. "Characterization of the biochemical properties of the human Upf1 gene product that is involved in nonsense-mediated mRNA decay."RNA 6:1226-1235(2000) [PubMed] [Europe PMC] [Abstract]
  10. "Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay."Genes Dev. 15:2215-2228(2001) [PubMed] [Europe PMC] [Abstract]
  11. "Cloning of a novel phosphatidylinositol kinase-related kinase: characterization of the human SMG-1 RNA surveillance protein."J. Biol. Chem. 276:22709-22714(2001) [PubMed] [Europe PMC] [Abstract]
  12. "Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4)."Mol. Cell. Biol. 21:209-223(2001) [PubMed] [Europe PMC] [Abstract]
  13. "Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1."Science 293:1836-1839(2001) [PubMed] [Europe PMC] [Abstract]
  14. "Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7."Mol. Cell 12:1187-1200(2003) [PubMed] [Europe PMC] [Abstract]
  15. "Characterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1."RNA 9:77-87(2003) [PubMed] [Europe PMC] [Abstract]
  16. "SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway."Mol. Cell 17:537-547(2005) [PubMed] [Europe PMC] [Abstract]
  17. "Regulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1."Nat. Struct. Mol. Biol. 12:794-800(2005) [PubMed] [Europe PMC] [Abstract]
  18. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  19. "Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay."Genes Dev. 20:355-367(2006) [PubMed] [Europe PMC] [Abstract]
  20. "Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells."EMBO Rep. 8:1052-1060(2007) [PubMed] [Europe PMC] [Abstract]
  21. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  22. "Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'."Genes Dev. 22:50-65(2008) [PubMed] [Europe PMC] [Abstract]
  23. "A competition between stimulators and antagonists of Upf complex recruitment governs human nonsense-mediated mRNA decay."PLoS Biol. 6:E111-E111(2008) [PubMed] [Europe PMC] [Abstract]
  24. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  25. "The editing enzyme ADAR1 and the mRNA surveillance protein hUpf1 interact in the cell nucleus."Proc. Natl. Acad. Sci. U.S.A. 105:5028-5033(2008) [PubMed] [Europe PMC] [Abstract]
  26. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  27. "SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay."Genes Dev. 23:1091-1105(2009) [PubMed] [Europe PMC] [Abstract]
  28. "Human proline-rich nuclear receptor coregulatory protein 2 mediates an interaction between mRNA surveillance machinery and decapping complex."Mol. Cell 33:75-86(2009) [PubMed] [Europe PMC] [Abstract]
  29. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  30. "Upf1 ATPase-dependent mRNP disassembly is required for completion of nonsense- mediated mRNA decay."Cell 143:938-950(2010) [PubMed] [Europe PMC] [Abstract]
  31. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  32. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  33. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  34. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  35. "Structural and functional insights into the human Upf1 helicase core."EMBO J. 26:253-264(2007) [PubMed] [Europe PMC] [Abstract]
  36. "Unusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2."EMBO J. 28:2293-2306(2009) [PubMed] [Europe PMC] [Abstract]
  37. "Molecular mechanisms for the RNA-dependent ATPase activity of Upf1 and its regulation by Upf2."Mol. Cell 41:693-703(2011) [PubMed] [Europe PMC] [Abstract]