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UV Radiation Resistance Associated Gene Protein (UVRAG)

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DHTX; p63; VPS38; Beclin 1 Binding Protein

UV Radiation Resistance Associated Gene Protein (UVRAG)
CCC L868
HGNC 12640
MGI 1925860
PubMed 17106237
RGD 1589754
UniProt Q9P2Y5
Wiki UVRAG
UVRAG complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer
UVRAG mRNA encodes a predicted 648-amino acid protein. UVRAG protein either is localized within an organelle or is part of the cytoskeleton. Northern blot analysis showed that UVRAG is expressed ubiquitously in humans; it was also present in most of the vertebrate species tested.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant UV Radiation Resistance Associated Gene Protein (UVRAG) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to UV Radiation Resistance Associated Gene Protein (UVRAG) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to UV Radiation Resistance Associated Gene Protein (UVRAG) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for UV Radiation Resistance Associated Gene Protein (UVRAG) CLIA Kit Customized Service Offer
n/a ELISA Kit for UV Radiation Resistance Associated Gene Protein (UVRAG) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant UV Radiation Resistance Associated Gene Protein (UVRAG) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to UV Radiation Resistance Associated Gene Protein (UVRAG) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to UV Radiation Resistance Associated Gene Protein (UVRAG) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for UV Radiation Resistance Associated Gene Protein (UVRAG) CLIA Kit Customized Service Offer
n/a ELISA Kit for UV Radiation Resistance Associated Gene Protein (UVRAG) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant UV Radiation Resistance Associated Gene Protein (UVRAG) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to UV Radiation Resistance Associated Gene Protein (UVRAG) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to UV Radiation Resistance Associated Gene Protein (UVRAG) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for UV Radiation Resistance Associated Gene Protein (UVRAG) CLIA Kit Customized Service Offer
n/a ELISA Kit for UV Radiation Resistance Associated Gene Protein (UVRAG) ELISA Kit Customized Service Offer
  1. "Molecular cloning of a novel human gene encoding a 63-kDa protein and its sublocalization within the 11q13 locus."Genomics 41:397-405(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Identification of a gene disrupted by inv(11)(q13.5;q25) in a patient with left-right axis malformation."Hum. Genet. 106:277-287(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
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  5. "Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG."Mol. Biol. Cell 19:5360-5372(2008) [PubMed] [Europe PMC] [Abstract]
  6. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase."Proc. Natl. Acad. Sci. U.S.A. 105:19211-19216(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages."Nat. Cell Biol. 11:385-396(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC."EMBO J. 31:1931-1946(2012) [PubMed] [Europe PMC] [Abstract]
  14. "Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism."Cell 154:1085-1099(2013) [PubMed] [Europe PMC] [Abstract]
  15. "Role of membrane association and Atg14-dependent phosphorylation in beclin-1-mediated autophagy."Mol. Cell. Biol. 33:3675-3688(2013) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]