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OTU Domain Containing Protein 5 (OTUD5)

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DUBA; Deubiquitinating enzyme A

OTU Domain Containing Protein 5 (OTUD5)
CCC L845
HGNC 25402
MGI 1859615
PubMed 22245969
RGD 1563027
UniProt Q96G74
OTUD5 encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described. In addition to an OTU domain, DUBA contains a ubiquitin action motif (UIM) at its carboxy terminus. The 2,759-basepair mRNA contains an open reading frame (ORF) predicting a 571-amino acid protein.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant OTU Domain Containing Protein 5 (OTUD5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to OTU Domain Containing Protein 5 (OTUD5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to OTU Domain Containing Protein 5 (OTUD5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for OTU Domain Containing Protein 5 (OTUD5) CLIA Kit Customized Service Offer
n/a ELISA Kit for OTU Domain Containing Protein 5 (OTUD5) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant OTU Domain Containing Protein 5 (OTUD5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to OTU Domain Containing Protein 5 (OTUD5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to OTU Domain Containing Protein 5 (OTUD5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for OTU Domain Containing Protein 5 (OTUD5) CLIA Kit Customized Service Offer
n/a ELISA Kit for OTU Domain Containing Protein 5 (OTUD5) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant OTU Domain Containing Protein 5 (OTUD5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to OTU Domain Containing Protein 5 (OTUD5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to OTU Domain Containing Protein 5 (OTUD5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for OTU Domain Containing Protein 5 (OTUD5) CLIA Kit Customized Service Offer
n/a ELISA Kit for OTU Domain Containing Protein 5 (OTUD5) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  6. "DUBA: a deubiquitinase that regulates type I interferon production."Science 318:1628-1632(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis."Cell 154:169-184(2013) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  14. "The catalytic domain of human OTUD5."Submitted (DEC-2010) to the PDB data bank
  15. "Phosphorylation-dependent activity of the deubiquitinase DUBA."Nat. Struct. Mol. Biol. 19:171-175(2012) [PubMed] [Europe PMC] [Abstract]