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OTU Domain Containing Protein 7B (OTUD7B)

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Cezanne; ZA20D1; Zinc Finger,A20 Domain Containing 1; Cellular zinc finger anti-NF-kappa-B protein; Zinc finger protein Cezanne

OTU Domain Containing Protein 7B (OTUD7B)
CCC L840
HGNC 16683
MGI 2654703
PubMed 23334419
RGD 1308111
UniProt Q6GQQ9
Wiki OTUD7B
The deduced protein contains more than 800 amino acids and has an N-terminal TRAF-binding domain, a putative nuclear localization signal, and a C-terminal A20-like zinc finger domain. Northern blot analysis detected a major 6-kb transcript in human epithelial cells and fibroblasts and in a liver carcinoma cell line. Epithelial cells and fibroblasts also expressed a minor 9.5-kb transcript. Both transcripts were detected in human tissues, with prominent expression in heart.
RT-PCR showed highest levels of Cezanne in kidney, heart, and fetal liver. Fluorescence-tagged Cezanne distributed diffusely within the cytoplasm of fibroblasts and epithelial cells and showed some nuclear staining in endothelial cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL840Hu01 Recombinant OTU Domain Containing Protein 7B (OTUD7B) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to OTU Domain Containing Protein 7B (OTUD7B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to OTU Domain Containing Protein 7B (OTUD7B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for OTU Domain Containing Protein 7B (OTUD7B) CLIA Kit Customized Service Offer
n/a ELISA Kit for OTU Domain Containing Protein 7B (OTUD7B) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant OTU Domain Containing Protein 7B (OTUD7B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to OTU Domain Containing Protein 7B (OTUD7B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to OTU Domain Containing Protein 7B (OTUD7B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for OTU Domain Containing Protein 7B (OTUD7B) CLIA Kit Customized Service Offer
n/a ELISA Kit for OTU Domain Containing Protein 7B (OTUD7B) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant OTU Domain Containing Protein 7B (OTUD7B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to OTU Domain Containing Protein 7B (OTUD7B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to OTU Domain Containing Protein 7B (OTUD7B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for OTU Domain Containing Protein 7B (OTUD7B) CLIA Kit Customized Service Offer
n/a ELISA Kit for OTU Domain Containing Protein 7B (OTUD7B) ELISA Kit Customized Service Offer
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  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
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  7. "Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity."Biochem. J. 378:727-734(2004) [PubMed] [Europe PMC] [Abstract]
  8. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  9. "NF-kappaB suppression by the deubiquitinating enzyme Cezanne: a novel negative feedback loop in pro-inflammatory signaling."J. Biol. Chem. 283:7036-7045(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne."Nat. Struct. Mol. Biol. 17:939-947(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  16. "DJ-1 enhances cell survival through the binding of cezanne, a negative regulator of NF-{kappa}B."J. Biol. Chem. 286:4098-4106(2011) [PubMed] [Europe PMC] [Abstract]
  17. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  18. "A global survey of CRM1-dependent nuclear export sequences in the human deubiquitinase family."Biochem. J. 441:209-217(2012) [PubMed] [Europe PMC] [Abstract]
  19. "Deubiquitination of EGFR by Cezanne-1 contributes to cancer progression."Oncogene 31:4599-4608(2012) [PubMed] [Europe PMC] [Abstract]
  20. "OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis."Cell 154:169-184(2013) [PubMed] [Europe PMC] [Abstract]
  21. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]