Otubain 2 (OTUB2)
[Edit]OTB2; OTU2; C14orf137; OTU domain, ubiquitin aldehyde binding 2; Deubiquitinating enzyme OTUB2; Ubiquitin-specific-processing protease OTUB2
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Otubains are deubiquitylating cysteine proteases (DUBs) that belong to the ovarian tumor (OTU) protein superfamily. Like other DUBs, otubains cleave proteins precisely at the ubiquitin (UB)-protein bond.
By affinity purification of DUBs from HeLa cells using UB aldehyde (UBAL), followed by SDS-PAGE and mass spectrophotometric analysis, Balakirev et al. (2003) obtained cDNAs encoding OTB1 and OTB2. The 234-amino acid, 27-kD OTB1 protein contains UB-interaction motifs (UIMs) and UB-associated (UBA) domains, as well as putative nuclear localization signals and a consensus LxxLL motif. RT-PCR and Western blot analyses revealed wide expression of OTB2, with highest expression in brain.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Otubain 2 (OTUB2) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Otubain 2 (OTUB2) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Otubain 2 (OTUB2) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Otubain 2 (OTUB2) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Otubain 2 (OTUB2) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Otubain 2 (OTUB2) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Otubain 2 (OTUB2) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Otubain 2 (OTUB2) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Otubain 2 (OTUB2) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Otubain 2 (OTUB2) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Otubain 2 (OTUB2) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Otubain 2 (OTUB2) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Otubain 2 (OTUB2) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Otubain 2 (OTUB2) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Otubain 2 (OTUB2) | ELISA Kit Customized Service Offer |
- "Otubains: a new family of cysteine proteases in the ubiquitin pathway."EMBO Rep. 4:517-522(2003) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Structural basis and specificity of human otubain 1-mediated deubiquitination."Biochem. J. 418:379-390(2009) [PubMed] [Europe PMC] [Abstract]
- "OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis."Cell 154:169-184(2013) [PubMed] [Europe PMC] [Abstract]
- "Crystal structure of human otubain 2."EMBO Rep. 5:783-788(2004) [PubMed] [Europe PMC] [Abstract]