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Quaking Homolog, KH Domain RNA Binding (QKI)

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Hqk; QK; QK3

Quaking Homolog, KH Domain RNA Binding (QKI)
CCC L834
HGNC 21100
MGI 97837
PubMed 16641098
RGD 1584886
UniProt Q96PU8
Wiki QKI
QKI belongs to a family of RNA-binding proteins called STAR proteins for Signal Transduction and Activation of RNA. They have an HNRNPK homology (KH) domain embedded in a 200-amino acid region called the GSG domain. Other members of this family include SAM68 (KHDRBS1) and SF1.
The QKI gene is implicated as being important in schizophrenia, and QKI controls translation of many oligodendrocyte-related genes.The balance between the nuclear and cytoplasmic isoforms of Qk1 controlled the nuclear export of Mbp mRNAs and the cellular localization of the 17- and 21.5-kD Mbp isoforms. Overexpression of Qki-5 in cultured rodent oligodendrocytes recreated the Mbp defects observed in qk(v) mice, with retention of Mbp in the nucleus.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Quaking Homolog, KH Domain RNA Binding (QKI) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Quaking Homolog, KH Domain RNA Binding (QKI) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Quaking Homolog, KH Domain RNA Binding (QKI) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Quaking Homolog, KH Domain RNA Binding (QKI) CLIA Kit Customized Service Offer
n/a ELISA Kit for Quaking Homolog, KH Domain RNA Binding (QKI) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Quaking Homolog, KH Domain RNA Binding (QKI) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Quaking Homolog, KH Domain RNA Binding (QKI) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Quaking Homolog, KH Domain RNA Binding (QKI) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Quaking Homolog, KH Domain RNA Binding (QKI) CLIA Kit Customized Service Offer
n/a ELISA Kit for Quaking Homolog, KH Domain RNA Binding (QKI) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Quaking Homolog, KH Domain RNA Binding (QKI) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Quaking Homolog, KH Domain RNA Binding (QKI) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Quaking Homolog, KH Domain RNA Binding (QKI) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Quaking Homolog, KH Domain RNA Binding (QKI) CLIA Kit Customized Service Offer
n/a ELISA Kit for Quaking Homolog, KH Domain RNA Binding (QKI) ELISA Kit Customized Service Offer
  1. "Expression of Hqk encoding a KH RNA binding protein is altered in human glioma."Jpn. J. Cancer Res. 93:167-177(2002) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Sam68 RNA binding protein is an in vivo substrate for protein arginine N-methyltransferase 1."Mol. Biol. Cell 14:274-287(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Human QKI, a new candidate gene for schizophrenia involved in myelination."Am. J. Med. Genet. B Neuropsychiatr. Genet. 141:84-90(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Human QKI, a potential regulator of mRNA expression of human oligodendrocyte-related genes involved in schizophrenia."Proc. Natl. Acad. Sci. U.S.A. 103:7482-7487(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "A Y2H-seq approach defines the human protein methyltransferase interactome."Nat. Methods 10:339-342(2013) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  11. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]